Amygdala hyperreactivity in restrictive anorexia nervosa
Amygdala hyperreactivity in restrictive anorexia nervosa
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DOI：
10.1016/j.pscychresns.2010.11.008
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发表时间：
2011-03-31
影响因子：
2.3
通讯作者：
Zeeck, Almut
中科院分区：
文献类型：
--
作者：
Joos, Andreas A. B.;Saum, Barbara;Zeeck, Almut
功能成像研究经常采用不同的范式和方法研究神经性厌食症（AN）患者的异质性样本，导致不同的结果。本研究的目的是研究这些问题，通过研究一个明确的样本限制性AN患者的疾病特异性范式，这是以前使用的。受试者表现出扣带回、额叶、岛叶和顶叶皮层的血氧水平依赖性反应增加。组间比较显示限制性AN患者右侧杏仁核的活动增加。我们的研究结果支持了其他最近发表的功能成像研究，并指出了右杏仁核在AN中的关键作用。与健康对照组相比，中扣带的信号减少。杏仁核活动增加和扣带皮层活动减少的组合可能代表了情绪处理的负反馈回路的一部分。厌恶等级与杏仁核信号呈负相关，这表明了这种结构在饮食失调中的复杂作用。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Functional imaging studies had often investigated heterogeneous samples of anorexia nervosa (AN) patients with varying paradigms and methodologies that had resulted in divergent results. The present study aimed to examine these issues by studying a well-defined sample of restrictive AN patients with a disorder-specific paradigm which had been used previously. Subjects showed increased blood oxygen level dependent responses of the cingulate, frontal, insular and parietal cortices. Group comparisons demonstrated increased activity of the right amygdala in the sample of restrictive AN patients. Our results are in support of other recently published functional imaging studies and point to a pivotal role of the right amygdala in AN. Signals of the midcingulum were reduced in comparison to healthy controls. The constellation of increased activity of the amygdala and decreased activity of the cingulate cortex likely represents parts of a negative feedback loop of emotional processing. Disgust ratings correlated with the amygdala signal negatively, which points to the complex role of this structure within eating disorders. (C) 2010 Elsevier Ireland Ltd. All rights reserved.