LONG-TERM PHYSICAL FUNCTIONING IN PERSONS WITH KNEE OSTEOARTHRITIS FROM NHANES-I - EFFECTS OF COMORBID MEDICAL CONDITIONS
LONG-TERM PHYSICAL FUNCTIONING IN PERSONS WITH KNEE OSTEOARTHRITIS FROM NHANES-I - EFFECTS OF COMORBID MEDICAL CONDITIONS
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DOI：
10.1016/0895-4356(94)90178-3
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发表时间：
1994-07-01
影响因子：
7.2
通讯作者：
MALLON, KP
中科院分区：
文献类型：
--
作者：
ETTINGER, WH;DAVIS, MA;MALLON, KP
这项研究考察了并存的医疗条件(心脏病、肺部疾病、高血压和肥胖)对放射学膝关节骨关节炎(OA)与长期身体功能障碍的关系的影响。资料来源于1971-1975年全国健康与营养检查普查(NHANES I)，前瞻性流行病学队列研究和1982-1984年NHANES流行病学随访研究(NHEFS)，包括4059名年龄在45-74岁并参与NHANES I详细检查组成部分的人群，膝骨性关节炎通过双侧膝关节正后位X线片确定，膝关节疼痛、心脏病和肺部疾病的自我报告通过自我报告疾病或症状，高血压和肥胖通过血压和体重测量确定。在NHEFS 1982-84年间，在NHANES I出现有症状的膝骨性骨关节炎与使用下肢的功能(行走和转移)有关。并存的慢性疾病，特别是心脏病、肺病和肥胖症的存在，增加了随后残疾的可能性。这些发现表明膝骨性关节炎与长期的身体残疾有关，并存的慢性病的存在可能会增加膝骨性骨性关节炎的长期伤残量。
This study examined the effects of comorbid medical conditions (heart disease, pulmonary disease, hypertension and obesity) on the association of radiographic knee osteoarthritis (OA) with long-term difficulty in physical function. Data are from the National Health and Nutrition Examination Survey, 1971-1975 (NHANES I), a prospective epidemiologic cohort study, and the NHANES Epidemiologic Follow-up Study, 1982-1984 (NHEFS) and included 4059 persons who were 45-74 years old and participated in the detailed examination component of NHANES I, Knee OA was ascertained by anterior-posterior bilateral radiographs of the knee and self-report of knee pain, heart and pulmonary disease by self report of disease or symptoms, and hypertension and obesity by blood pressure and weight measurements. The presence of symptomatic knee OA at NHANES I was associated with reported difficulty at NHEFS 1982-84 in functions which used the lower extremity (ambulation and transfer). The presence of coexistent chronic conditions, particularly heart disease, pulmonary disease and obesity, increased the likelihood of subsequent disability. These findings suggest that knee OA is associated with long-term physical disability, and that the presence of coexistent chronic disease may increase the amount of long-term disability from knee OA.