Reversible resistance to apoptosis in cutaneous T cell lymphoma.
Reversible resistance to apoptosis in cutaneous T cell lymphoma.
复制标题
皮肤 T 细胞淋巴瘤对细胞凋亡的可逆抵抗。
DOI：
10.1111/j.1749-6632.2001.tb03710.x
复制
发表时间：
2001
影响因子：
5.2
通讯作者：
Duke,RC
中科院分区：
文献类型：
--
作者：
Meech,SJ;Edelson,R;Walsh,P;Norris,DA;Duke,RC
翻译后摘要：蕈样肉芽肿及其白血病的变种，Sézary综合征，是最常见的形式的皮肤T细胞淋巴瘤（CTCL）。这些疾病是克隆性肿瘤，其特征在于类似于活化/记忆CD 4 +T细胞的细胞进行性积聚。与它们的正常对应物不同，这些恶性淋巴细胞具有延长的寿命，并且在用大多数化疗剂治疗后对死亡具有抗性。这表明CTCL经历异常的程序性细胞死亡;然而，关于CTCL中的凋亡缺陷的数据是有限的。调节淋巴细胞的凋亡，定期进行克隆扩张必然是复杂的，将在这里进行审查。克隆扩增的淋巴细胞主要依赖于Fas介导的途径来启动凋亡。将讨论导致CTCL细胞凋亡抵抗的因素以及逆转这种抵抗的新治疗方法，包括Fas死亡途径在CTCL的发病机制和治疗中可能发挥的重要作用。
Abstract:Mycosis fungoides and its leukemic variant, Sézary syndrome, represent the most common forms of cutaneous T cell lymphomas (CTCL). These disorders are clonal neoplasms characterized by the progressive accumulation of cells that resemble activated/memory CD4+T cells. Unlike their normal counterparts, these malignant lymphocytes have prolonged life spans and are resistant to dying following treatment with most chemotherapeutic agents. This suggests that CTCL undergo abnormal programmed cell death; however, data regarding apoptotic defects in CTCL are limited. Regulation of apoptosis in lymphocytes that regularly undergo clonal expansion is necessarily complex and will be reviewed here. Clonally expanded lymphocytes rely primarily on Fas‐mediated pathways to initiate apoptosis. Factors leading to the resistance of apoptosis in CTCL and new therapeutic approaches for reversing this resistance will be discussed, including the important role that the Fas death pathway may play in the pathogenesis and treatment of CTCL.