Baseline Characteristics and Mortality Among People in Care for Chronic Viral Hepatitis: The Chronic Hepatitis Cohort Study
Baseline Characteristics and Mortality Among People in Care for Chronic Viral Hepatitis: The Chronic Hepatitis Cohort Study
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DOI：
10.1093/cid/cis815
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发表时间：
2013-01-01
影响因子：
11.8
通讯作者：
Holmberg, Scott D.
中科院分区：
文献类型：
--
作者：
Moorman, Anne C.;Gordon, Stuart C.;Holmberg, Scott D.
背景慢性肝炎队列研究（CHeCS）是一项动态前瞻性、纵向、观察性队列研究，旨在评估美国慢性病毒性肝炎的临床影响。本报告描述了队列选择过程、基线人口统计学、保险、活检、住院和死亡率。从2006年1月至2010年12月，在密歇根州底特律、宾夕法尼亚州丹维尔、俄勒冈州波特兰和夏威夷檀香山的4个综合医疗保健系统中，收集并分析了超过160万名成年患者的电子健康记录。在2202例慢性B型肝炎病毒（HBV）感染患者中，50%的患者年龄在44-63岁之间，57%为男性，58%为亚洲/太平洋岛民，13%为黑人; 5.1%有医疗补助，16.5%有医疗保险，76.3%有私人保险。在2001-2010年期间，22.3%的患者进行了肝活检，37.9%的患者住院治疗。在8810例慢性丙型肝炎病毒（HCV）感染患者中，75%的患者年龄在44-63岁之间，60%为男性，23%为黑人; 12%有医疗补助，23%有医疗保险，62%有私人保险。在2001-2010年期间，38.4%的患者进行了肝活检，44.3%的患者住院治疗。在护理人员中，9%的HBV感染者和14%的HCV感染者（主要是1945-1964年出生的人）在2006-2010年的五年期间死亡。来自CHeCS的基线人口统计学、住院和死亡率数据突出了慢性病毒性肝炎给美国带来的巨大健康负担，特别是在1945-1964年出生的人群中。
Background. The Chronic Hepatitis Cohort Study (CHeCS), a dynamic prospective, longitudinal, observational cohort study, was created to assess the clinical impact of chronic viral hepatitis in the United States. This report describes the cohort selection process, baseline demographics, and insurance, biopsy, hospitalization, and mortality rates.Methods. Electronic health records of >1.6 million adult patients seen from January 2006 through December 2010 at 4 integrated healthcare systems in Detroit, Michigan; Danville, Pennsylvania; Portland, Oregon; and Honolulu, Hawaii were collected and analyzed.Results. Of 2202 patients with chronic hepatitis B virus (HBV) infection, 50% were aged 44-63 years, 57% male, 58% Asian/Pacific Islander, and 13% black; and 5.1% had Medicaid, 16.5% Medicare, and 76.3% private insurance. During 2001-2010, 22.3% had a liver biopsy and 37.9% were hospitalized. For the 8810 patients with chronic hepatitis C virus (HCV) infection, 75% were aged 44-63 years, 60% male, 23% black; and 12% had Medicaid, 23% Medicare, and 62% private insurance. During 2001-2010, 38.4% had a liver biopsy and 44.3% were hospitalized. Among persons in care, 9% of persons with HBV and 14% of persons with HCV infection, mainly those born during 1945-1964, died during the 2006-2010 five-year period.Conclusions. Baseline demographic, hospitalization, and mortality data from CHeCS highlight the substantial US health burden from chronic viral hepatitis, particularly among persons born during 1945-1964.