The Metabolome: a Key Measure for Exposome Research in Epidemiology
The Metabolome: a Key Measure for Exposome Research in Epidemiology
复制标题
DOI：
10.1007/s40471-019-00187-4
复制
发表时间：
2019-06-01
影响因子：
3.3
通讯作者：
Jones, Dean P.
中科院分区：
文献类型：
--
作者：
Walker, Douglas I.;Valvi, Damaskini;Jones, Dean P.
综述目的组学在人类健康研究中的应用为流行病学研究开创了一个新的机遇时代。然而，表征外源性健康触发因素的方法在很大程度上没有利用分析平台和大数据的进步。在这篇综述中，我们强调了暴露体，它被定义为一生中暴露和生物反应的累积测量，作为研究复杂和可预防的人类疾病的新流行病学方法的基石。虽然没有通用的方法来测量整个暴露体，但使用高分辨率质谱方法比传统的生物监测具有明显的优势，并为暴露体研究提供了必要的关键进展。本文还讨论了在不同研究设计中的应用，以及将暴露数据与新的数据分析框架结合起来研究多重压力源的复杂相互作用的建议。尽管仍需应对挑战，但暴露体表征方法的进展为流行病学支持改善公共卫生的基本发现提供了令人兴奋的新机会。
Purpose of ReviewApplication of omics to study human health has created a new era of opportunities for epidemiology research. However, approaches to characterize exogenous health triggers have largely not leveraged advances in analytical platforms and big data. In this review, we highlight the exposome, which is defined as the cumulative measure of exposure and biological responses across a lifetime as a cornerstone for new epidemiology approaches to study complex and preventable human diseases.Recent FindingsWhile no universal approach exists to measure the entirety of the exposome, use of high-resolution mass spectrometry methods provide distinct advantages over traditional biomonitoring and have provided key advances necessary for exposome research. Application to different study designs and recommendations for combining exposome data with novel data analytic frameworks to study complex interactions of multiple stressors are also discussed.SummaryEven though challenges still need to be addressed, advances in methods to characterize the exposome provide exciting new opportunities for epidemiology to support fundamental discoveries to improve public health.