Advancing the Drug Discovery and Development Process
Advancing the Drug Discovery and Development Process
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DOI：
10.1002/anie.201404761
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发表时间：
2014-08-25
影响因子：
16.6
通讯作者：
Nicolaou, K. C.
中科院分区：
文献类型：
--
作者：
Nicolaou, K. C.
简要概述了药物发现和开发过程的现状，然后讨论了如何利用化学和生物学及相关学科中不断增加的基础知识和技术诀窍。这篇文章的主要动机是庆祝化学、生物学和医学的伟大成就，并告知和激励学生和学者进入药物发现和开发领域，同时继续推进其学科的基础。它还旨在鼓励和促进学术界和工业界之间的多学科伙伴关系，因为科学家们试图合并他们往往互补的兴趣和专业知识，以在各自的领域实现新的改进和突破，并实现将其应用于发现和发明新的和更好的药物的共同目标，特别是在未满足需求的领域。
The current state of affairs in the drug discovery and development process is briefly summarized and then ways to take advantage of the ever-increasing fundamental knowledge and technical knowhow in chemistry and biology and related disciplines are discussed. The primary motivation of this Essay is to celebrate the great achievements of chemistry, biology, and medicine and to inform and inspire students and academics to enter the field of drug discovery and development while, at the same time, continue to advance the fundamentals of their disciplines. It is also meant to encourage and catalyze multidisciplinary partnerships between academia and industry as scientists attempt to merge their often complementary interests and expertise to achieve new improvements and breakthroughs in their respective fields, and the common goal of applying them to the discovery and invention of new and better medicines, especially in areas of unmet needs.