Optical Mapping.
Optical Mapping.
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DOI：
10.1016/j.ccep.2019.04.004
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发表时间：
2019-09-01
影响因子：
--
通讯作者：
Efimov, Igor
中科院分区：
文献类型：
--
作者：
Berenfeld, Omer;Efimov, Igor
心脏电活动的光学映射是基于电压敏感和亲脂性荧光染料。从心脏细胞记录的光信号与它们的跨膜电位密切相关。高时空分辨率、宽视场映射和对跨膜电位的高灵敏度使动作电位的产生和传播得以详细表征。光学成像用于研究复杂的兴奋传播模式，包括通过窦房结和房室结以及心房和室性心律失常期间的传播。光学制图用于研究心房和心室颤动中重入活动的作用。
Optical mapping of electrical activity in the heart is based on voltage-sensitive and lipophilic fluorescence dyes. Optical signals recorded from cardiac cells correlate well with their transmembrane potentials. High spatiotemporal resolution, wide field mapping, and high sensitivity to transmembrane potential enable detailed characterization of action potential initiation and propagation. Optical mapping is used to study complex patterns of excitation propagation, including propagation across the sinoatrial and atrioventricular nodes and during atrial and ventricular arrhythmias.Optical mapping is used to study the role of reentrant activity in atrial and ventricular fibrillation.