pH and Glutathione Dual-Responsive Dynamic Cross-Linked Supramolecular Network on Mesoporous Silica Nanoparticles for Controlled Anticancer Drug Release
pH and Glutathione Dual-Responsive Dynamic Cross-Linked Supramolecular Network on Mesoporous Silica Nanoparticles for Controlled Anticancer Drug Release
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介孔二氧化硅纳米粒子上的 pH 和谷胱甘肽双响应动态交联超分子网络用于控制抗癌药物释放
DOI：
10.1021/acsami.5b10534
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发表时间：
2015-12-30
影响因子：
9.5
通讯作者：
Yang, Ying-Wei
中科院分区：
文献类型：
--
作者：
Li, Qing-Lan;Xu, Shi-Han;Yang, Ying-Wei
摘要在介孔二氧化硅纳米颗粒上，通过瓜bbb_urils与聚合物链上的质子化二胺之间的二硫键和离子偶极子相互作用，构建了聚甲基丙烯酸甘油酯衍生物链的动态交联超分子网络。这种具有pH-和谷胱甘肽- (GSH-)刺激响应性的多功能有机无机杂化材料可用于抗癌药物的传递和控释。在模拟肿瘤细胞内环境（pH = 5.0, C-GSH = 2-10 mM）下，对盐酸阿霉素（DOX）具有良好的释放性能。一系列对照释放实验表明，随着溶液pH值的降低和GSH浓度的增加，DOX的释放量显著增加。此外，MTT实验和共聚焦激光扫描显微镜结果表明，负载dox的杂化纳米材料对癌细胞具有明显的细胞生长抑制作用。
A dynamic cross-linked supramolecular network of poly(glycidyl methacrylate)s derivative chains was constructed on mesoporous silica nanoparticles via disulfide bond and ion-dipole interactions between cucurbit[7]urils and protonated diamines in the polymer chains. This kind of multifunctional organic-inorganic hybrid material with pH- and glutathione- (GSH-) stimuli responsiveness can be applied to anticancer drug delivery and controlled release. Good release performance toward doxorubicin hydrochloride (DOX) was achieved under the simulative tumor intracellular environment (pH = 5.0, C-GSH = 2-10 mM). Significantly, the release amount of DOX increased upon lowering the solution pH value and increasing the concentration of GSH, as demonstrated by a series of controlled release experiments. Furthermore, the DOX-loaded hybrid nanomaterials displayed apparent cell-growth inhibition effects to cancer cell lines, as evidenced by MTT assay and confocal laser scanning microscopy.