DIRECT THIONATION AND AMINOALKYLATION OF PYRIDINE 1-OXIDES AND RELATED REACTIONS
DIRECT THIONATION AND AMINOALKYLATION OF PYRIDINE 1-OXIDES AND RELATED REACTIONS
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DOI：
10.1002/jhet.5570120414
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发表时间：
1975-01-01
影响因子：
2.4
通讯作者：
KNAUS, EE
中科院分区：
文献类型：
--
作者：
ABRAMOVITCH, RA;KNAUS, EE
锂吡啶1 -氧化物与氧的反应产生1 -羟基- 2 -吡啶酮的产率很低。然而，与硫的反应是制备具有有效抗菌和抗真菌活性的1 -羟基- 2 -吡啶硫酮的便捷途径。与环氧乙烷的反应主要产生聚合产物，但添加Shiff的碱有望成为一种方便的模式，尤其是吡啶1 -氧化物的二α -氨基烷基化。
The reaction of lithiopyridine 1‐oxides with oxygen gives poor yields of 1‐hydroxy‐2‐pyridones. The reaction with sulfur, however, is a convenient route to the 1‐hydroxy‐2‐pyridinethiones which have useful antibacterial and antifungal activity. Reaction with ethylene oxide gives mainly polymeric products, but addition to Shiff's bases promises to be a convenient mode of mono‐, and particularly di‐α‐aminoalkylation of pyridine 1‐oxides.