MUTAGENIC ACTIVITY OF QUERCETIN AND RELATED COMPOUNDS
MUTAGENIC ACTIVITY OF QUERCETIN AND RELATED COMPOUNDS
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DOI：
10.1126/science.327550
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发表时间：
1977-01-01
期刊：
影响因子：
56.9
通讯作者：
CHANG, GW
中科院分区：
文献类型：
--
作者：
BJELDANES, LF;CHANG, GW
通过鼠伤寒沙门氏菌突变体，揭示碱基对取代和移码诱变剂的几种黄酮类化合物和黄酮类化合物代谢产物的诱变活性进行了研究。在检测的化合物（柚苷、芦丁、新橙皮素、橙皮素、二氢槲皮素、槲皮素、槲皮素五乙酸酯、全甲基槲皮素、间羟基苯乙酸和间，对二羟基苯乙酸）中，仅槲皮素具有致突变性，而无微粒体活化。经活化后，槲皮素的致突变活性显着增强，并显示出槲皮素五乙酸酯的致突变活性。这些研究结果对人类健康的影响和方面的类黄酮结构要求的诱变活性进行了讨论。
The mutagenic activities of several flavonoids and flavonoid metabolites were examined by means of Salmonella typhimurium mutants that reveal base-pair substitution and frameshift mutagens. Of the compounds tested (naringin, rutin, neohesperetin, hesperetin, dihydroquercetin, quercetin, quercetin pentaacetate, permethylquercetin, m-hydroxyphenylacetic acid, and m,p-dihydroxyphenylacetic acid) only quercetin was mutagenic without microsomal activation. With activation the mutagenic activity of quercetin was increased significantly and that of quercetin pentaacetate was revealed. The health implications for humans of these findings and aspects of flavonoid structural requirements for mutagenic activity are discussed.