Wall Mechanical Properties and Hemodynamics of Unruptured Intracranial Aneurysms.
Wall Mechanical Properties and Hemodynamics of Unruptured Intracranial Aneurysms.
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DOI：
10.3174/ajnr.a4358
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发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Robertson AM
中科院分区：
文献类型：
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作者：
Cebral JR;Duan X;Chung BJ;Putman C;Aziz K;Robertson AM
目的探讨人动脉瘤内血流动力学状态与动脉瘤壁力学性质的关系。共分析了8例未破裂动脉瘤。根据术前3D旋转血管造影图像构建计算流体动力学（CFD）模型。夹闭动脉瘤，切除圆顶，并在多光子显微镜下使用单轴测试系统进行机械测试直至失效。进行线性回归分析，以探讨血流动力学参数与壁的失效特征和刚度之间可能的相关性。极限应变与动脉瘤流入率（p=0.021）、平均流速（p=0.025）和平均壁面剪应力（p=0.039）呈负相关。它也呈负相关的流入浓度，振荡剪切指数和措施的复杂性和不稳定性的流动，但这些趋势并没有达到统计学意义。高应变时的壁刚度与流入速率（p=0.014）、平均流速（p=0.008）、流入浓度（p=0.04）、流动不稳定性（p=0.006）、流动复杂性（p=0.019）、壁剪切应力（p=0.002）和振荡剪切指数（p=0.004）呈正相关。在8个未破裂颅内动脉瘤的研究中，极限应变与动脉瘤流入速率、平均速度和平均壁面剪应力呈负相关。壁刚度与动脉瘤流入率、平均流速、壁面切应力、流动复杂性和稳定性以及振荡剪切指数呈正相关。这些趋势以及血液动力学对壁结构和力学性能的影响应在更大规模的研究中进一步研究。
To investigate the relationship between the intra-aneurysmal hemodynamic conditions and the mechanical properties of the wall in human aneurysms. A total of eight unruptured aneurysms were analyzed. Computational fluid dynamics (CFD) models were constructed from pre-operative 3D rotational angiography images. The aneurysms were clipped and the domes were resected and mechanically tested to failure with a uniaxial testing system under multi-photon microscopy. Linear regression analysis was performed to explore possible correlations between hemodynamic quantities and the failure characteristics and stiffness of the wall. The ultimate strain was negatively correlated to aneurysm inflow rate (p=0.021), mean velocity (p=0.025), and mean wall shear stress (p=0.039). It was also negatively correlated to inflow concentration, oscillatory shear index and measures of the complexity and instability of the flow; however these trends did not reach statistical significance. The wall stiffness at high strains was positively correlated to inflow rate (p=0.014), mean velocity (p=0.008), inflow concentration (p=0.04), flow instability (p=0.006), flow complexity (p=0.019), wall shear stress (p=0.002) and oscillatory shear index (p=0.004). In a study of 8 unruptured intracranial aneurysms, ultimate strain is negatively correlated with aneurysm inflow rate, mean velocity and mean wall shear stress. Wall stiffness is positively correlated with aneurysm inflow rate, mean velocity, wall shear stress, flow complexity and stability, and oscillatory shear index. These trends and the impact of hemodynamics on wall structure and mechanical properties should be further investigated in larger studies.