The Incidence of Primary vs Secondary Focal Segmental Glomerulosclerosis: A Clinicopathologic Study
The Incidence of Primary vs Secondary Focal Segmental Glomerulosclerosis: A Clinicopathologic Study
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DOI：
10.1016/j.mayocp.2017.09.011
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发表时间：
2017-12-01
影响因子：
8.9
通讯作者：
Fervenza, Fernando C.
中科院分区：
文献类型：
--
作者：
Hommos, Musab S.;De Vriese, An S.;Fervenza, Fernando C.
目的：描述明尼苏达州奥姆斯特德县1994年至2013年原发性和继发性局灶节段性肾小球硬化（FSGS）发病率的变化，并确定区分原发性和继发性FSGS的临床和活检特征。从1994年1月1日至2013年12月31日，奥姆斯特德县成年居民进行了本地肾脏活检，并确定FSGS为唯一的肾小球病。结果：370例活检的成人中，肾小球疾病281例，其中FSGS 46例（16%）。从1994 - 2003年至2004-2013年，肾活检率显著增加（14.7 [95%CI，12.1-17.3] vs 22.9 [95%CI，20.0-25.7]/10万人-年，每5年增加17%; P
Objectives: To describe the change in the incidence rates of primary and secondary focal segmental glomerulosclerosis (FSGS) from 1994 through 2013 in Olmsted County, Minnesota, and to identify the clinical and biopsy characteristics that distinguish primary from secondary FSGS.Patients and Methods: Olmsted County adult residents with native kidney biopsy from January 1, 1994, through December 31, 2013, and FSGS as the only glomerulopathy were identified. The clinical and pathologic characterstics of primary and secondary FSGS were described and compared, and incidence rates were calculated.Results: Of 370 adults biopsied, 281 had glomerular diseases, of which 46 (16%) had FSGS. From 19942003 to 2004-2013, there were significant increases in kidney biopsy rates (14.7 [95% CI, 12.1-17.3] vs 22.9 [95% CI, 20.0-25.7] per 100,000 person-years, 17% increase per 5 years; P