Self-healing biomaterials.
Self-healing biomaterials.
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DOI：
10.1002/jbm.a.32987
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发表时间：
2011-02
期刊：
影响因子：
--
通讯作者：
Reichert WM
中科院分区：
文献类型：
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作者：
Brochu AB;Craig SL;Reichert WM
本综述的目的是向生物材料界介绍自修复材料这一新兴领域，并提出如何利用和改进自修复方法来开发新型生物材料的建议。简要讨论了生物医学植入物的体内机械负荷和由此产生的故障，然后介绍了对抗机械故障的自修复方法。如果说延缓失效的传统复合材料可以被认为是第0代自愈材料，那么从分类上讲，第一代自愈材料描述了“停止”和“填充”损伤的方法，而第二代自愈材料则努力“完全恢复”失效前的材料结构。尽管迄今为止商业用途有限，主要是因为技术细节尚未适当优化，但从实际的角度来看，第一代方法可能首先用于商业，而第二代方法可能需要更长的时间来实施。对于自愈生物材料，由于毒性和生物相容性的额外限制，技术考虑的优化进一步复杂化，因此有必要单独讨论自愈生物材料的设计标准。
The goal of this review is to introduce the biomaterials community to the emerging field of self-healing materials, and also to suggest how one could utilize and modify self-healing approaches to develop new classes of biomaterials. A brief discussion of the in vivo mechanical loading and resultant failures experienced by biomedical implants is followed by presentation of the self-healing methods for combating mechanical failure. If conventional composite materials that retard failure may be considered zeroth generation self-healing materials, then taxonomically-speaking, first generation self-healing materials describe approaches that “halt” and “fill” damage, whereas second generation self-healing materials strive to “fully restore” the pre-failed material structure. In spite of limited commercial use to date, primarily because the technical details have not been suitably optimized, it is likely from a practical standpoint that first generation approaches will be the first to be employed commercially, whereas second generation approaches may take longer to implement. For self-healing biomaterials the optimization of technical considerations is further compounded by the additional constraints of toxicity and biocompatibility, necessitating inclusion of separate discussions of design criteria for self-healing biomaterials.