An ECG-based algorithm for the automatic identification of autonomic Activations associated with cortical arousal
An ECG-based algorithm for the automatic identification of autonomic Activations associated with cortical arousal
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DOI：
10.1093/sleep/30.10.1349
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发表时间：
2007-10-01
期刊：
影响因子：
5.6
通讯作者：
Samel, Alexander
中科院分区：
文献类型：
--
作者：
Basner, Mathias;Griefahn, Barbara;Samel, Alexander
目的：脑电觉醒与自主神经活动有关。视觉EEG唤醒评分是耗时的，并且观察者间一致性低。我们假设，仅在心率的变化信息足以预测皮质arousal.Methods的发生：两个视觉AASM脑电唤醒评分的56个健康受试者的夜晚（平均年龄37.0 +/- 12.8岁，26名男性）。对于3581次一致EEG觉醒和相同数量的对照条件的发作后的5次心跳中的每一次，计算与移动中位数的差异，并用于估计10类心跳差异的似然比（LR）。可比5个连续的诊断测试，这些LR被用来计算与皮层arousals.Results的心率反应的概率：EEG和ECG唤醒指数同意以及在很宽的范围内的决策阈值，导致在接收器操作特性（ROC）的曲线下面积为0.91。对于最终分析选择的决策阈值，获得了68.1%的灵敏度和95.2%的特异性。ECG和EEG觉醒指数相关性较差（r = 0.19，P
Objectives: EEG arousals are associated with autonomic activations. Visual EEG arousal scoring is time consuming and suffers from low interobserver agreement. We hypothesized that information on changes in heart rate alone suffice to predict the occurrence of cortical arousal.Methods: Two visual AASM EEG arousal scorings of 56 healthy subject nights (mean age 37.0 +/- 12.8 years, 26 male) were obtained. For each of 5 heartbeats following the onset of 3581 consensus EEG arousals and of an equal number of control conditions, differences to a moving median were calculated and used to estimate likelihood ratios (LRs) for 10 categories of heartbeat differences. Comparable to 5 consecutive diagnostic tests, these LRs were used to calculate the probability of heart rate responses being associated with cortical arousals.Results: EEG and ECG arousal indexes agreed well across a wide range of decision thresholds, resulting in a receiver operating characteristic (ROC) with an area under the curve of 0.91. For the decision threshold chosen for the final analyses, a sensitivity of 68.1% and a specificity of 95.2% were obtained. ECG and EEG arousal indexes were poorly correlated (r = 0.19, P