Development of novel entry inhibitors targeting emerging viruses.

Development of novel entry inhibitors targeting emerging viruses.
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DOI:
10.1586/eri.12.104
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发表时间:
2012-10
影响因子:
5.7
通讯作者:
Simmons G
Simmons G
中科院分区:
医学2区
文献类型:
--
作者:
Zhou Y;Simmons G

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新出现的病毒性疾病对公共卫生构成了独特的风险,因此需要开发治疗方法。目前资助机构和研究的一个重点是开发广谱抗病毒药物,特别是那些针对常见细胞途径的药物。本文的范围是回顾这一领域的筛查策略和最新进展,特别强调针对新出现的脂膜病毒(如埃博拉病毒和SARS冠状病毒)进入病毒的步骤的抗病毒药物。
Emerging viral diseases pose a unique risk to public health, and thus there is a need to develop therapies. A current focus of funding agencies, and hence research, is the development of broad-spectrum antivirals, and in particular, those targeting common cellular pathways. The scope of this article is to review screening strategies and recent advances in this area, with a particular emphasis on antivirals targeting the step of viral entry for emerging lipid-enveloped viruses such as Ebola virus and SARS-coronavirus.
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