Part I
Part I
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DOI：
10.1212/wnl.49.2_suppl_2.s4
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发表时间：
1997-08
期刊：
影响因子：
9.9
通讯作者：
L. Wilkins
中科院分区：
文献类型：
--
作者：
L. Wilkins
随着时间的推移，在世界各地的许多地方多发性硬化症（MS）的发生的研究已经产生了一些有趣的线索，这些线索已经被制定成关于这种疾病的病因的假设。进行发生研究和病因（因果）研究的策略有许多共同的要求，但也有不同。前者强调完整和准确的案件查明。对于主要目标是评估MS发展的可能风险因素的研究，准确的病例确定也至关重要，但需要考虑与描述性研究无关的其他几个方面。两个主要的是测量和收集。
The study of the occurrence of multiple sclerosis (MS) over time and in many places throughout the world has yielded several interesting clues that have been formulated into hypotheses concerning the causation of this illness. The strategies for carrying out occurrence research and etiologic(causal) research share many common requirements, but do differ. The former emphasize complete and accurate case ascertainment. For studies in which the main goal is assessment of possible risk factors for the development of MS, accurate case ascertainment is also crucial, but several other aspects not relevant to descriptive studies need to be considered. The two main ones are the measurement and collection …