Unique aspects of transcriptional regulation in neurons--nuances in NFkappaB and Sp1-related factors.
Unique aspects of transcriptional regulation in neurons--nuances in NFkappaB and Sp1-related factors.
复制标题
神经元转录调控的独特方面 - NFKAPPAB和SP1相关因素的责任。
DOI：
10.1186/1742-2094-6-16
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发表时间：
2009-05-18
影响因子：
9.3
通讯作者：
Barger SW
中科院分区：
文献类型：
--
作者：
Mao XR;Moerman-Herzog AM;Chen Y;Barger SW
神经元独特的生理学和功能造成了细胞生理学的差异，包括它们对基因表达的调节。几年前，我们开始探索端脑神经元中 NFκB 转录因子、神经元存活和谷氨酸受体激活之间的关系。这些研究使我们得出结论，该细胞群几乎无法激活 NFκB，但 NFκB 仍以合理的水平表达。相反，κB 顺式元件的子集与神经元中 Sp1 家族的成员结合。同样令人惊讶的是我们发现 Sp1 本身通常被描述为无处不在，但其在前脑神经元内的表达受到严格限制。 Sp4 似乎在神经元分化过程中被取代。本文讨论了这些发现及其对神经元分化以及退行性过程中潜在的去分化的影响。
The unique physiology and function of neurons create differences in their cellular physiology, including their regulation of gene expression. We began several years ago exploring the relationships between the NFκB transcription factor, neuronal survival, and glutamate receptor activation in telencephalic neurons. These studies led us to conclude that this population of cells is nearly incapable of activating the NFκB that is nonetheless expressed at reasonable levels. A subset of the κB cis elements are instead bound by members of the Sp1 family in neurons. Also surprising was our discovery that Sp1 itself, typically described as ubiquitous, is severely restricted in expression within forebrain neurons; Sp4 seems to be substituted during neuronal differentiation. These findings and their implications for neuronal differentiation – as well as potential dedifferentiation during degenerative processes – are discussed here.