Degradable selenium-containing polymers for low cytotoxic antibacterial materials
Degradable selenium-containing polymers for low cytotoxic antibacterial materials
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用于低细胞毒性抗菌材料的可降解含硒聚合物
DOI：
10.1021/acsmacrolett.2c00537
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发表时间：
2022
影响因子：
5.8
通讯作者：
朱健
中科院分区：
文献类型：
--
作者：
李莹莹;马晓亮;章建东;潘向强;李娜;陈高健;朱健
开发具有高抑菌效率和低细胞毒性的可生物降解阳离子聚合物具有重要的生物应用意义。硒是人体必需的微量元素，含硒化合物在各种与健康有关的应用中具有广阔的应用前景。为了将硒与生物可降解性结合起来，合成了具有不同疏水取代基的硒化聚己内酯（PCL），并进行了硒化处理。优化得到的聚硒鎓盐具有良好的抗菌活性，其MBC为2 μg ml - 1， MIC为1 μg ml - 1，降解前后均具有良好的生物相容性。此外，所得的硒聚合物可以通过静电纺丝与商用PCL进行良好的共混，制备出具有良好抗菌活性的薄膜。本工作丰富了对硒衍生物的认识，为后续抗菌领域对硒阳离子聚合物的研究奠定了基础。
Developing biodegradable cationic polymers with high antibacterial efficiency and low cytotoxicity is of great significance in biological applications. Selenium is an essential trace element for the human body, and selenium-containing compounds are promising in various health-related applications. To combine selenium with biodegradability, selenide-functionalized polycaprolactones (PCL) with different hydrophobic substituents were synthesized followed by selenoniumization. The optimal polyselenonium salt showed excellent antibacterial activity with an MBC of 2 μg mL–1and an MIC of 1 μg mL–1and exhibited good biocompatibility before and after degradation. In addition, the obtained selenium polymer can be well blended with commercial PCL by electrospinning, and films with good antibacterial activity were prepared. This work enriches the knowledge of selenium derivatives and lays a foundation for follow-up research on selenium cationic polymers in the antimicrobial field.