S1P metabolism in cancer and other pathological conditions.
S1P metabolism in cancer and other pathological conditions.
复制标题
DOI：
10.1016/j.biochi.2010.02.014
复制
发表时间：
2010-06
期刊：
影响因子：
3.9
通讯作者：
Saba, Julie D.
中科院分区：
文献类型：
--
作者：
Leong, Weng In;Saba, Julie D.
关键词：
近二十年前，发现鞘脂代谢物鞘氨醇1-磷酸作为脂质介质和细胞增殖调节剂发挥作用。从那时起，1-磷酸鞘氨醇已被证明介导多种基本生物学过程，包括细胞增殖、迁移、侵袭、血管生成、血管成熟和淋巴细胞运输。鞘氨醇1-磷酸主要通过五种普遍表达的G蛋白偶联受体的信号传导起作用。细胞内鞘氨醇1-磷酸分子被转运到细胞外，并进入其同源受体，以自分泌和旁分泌方式，并通过血液和淋巴循环系统在远端部位发出信号。细胞内可用于信号传导的鞘氨醇1-磷酸池受到三种酶的严格调节，包括鞘氨醇激酶、S1 P裂解酶和S1 P磷酸酶。在许多类型的恶性肿瘤中观察到S1 P水平以及参与其合成和催化的酶的改变。正在评估这些酶在介导癌症形成和进展中的作用，以及它们作为抗癌治疗靶点的潜力。在这篇综述中，1-磷酸鞘氨醇，其同源受体，和1-磷酸鞘氨醇代谢酶对细胞存活，凋亡，自噬，细胞转化，侵袭，血管生成和缺氧的影响，肿瘤生物学和治疗进行了讨论。
Nearly two decades ago, the sphingolipid metabolite sphingosine 1-phosphate was discovered to function as a lipid mediator and regulator of cell proliferation. Since that time, sphingosine 1-phosphate has been shown to mediate a diverse array of fundamental biological processes including cell proliferation, migration, invasion, angiogenesis, vascular maturation and lymphocyte trafficking. Sphingosine 1-phosphate acts primarily via signaling through five ubiquitously expressed G protein-coupled receptors. Intracellular sphingosine 1-phosphate molecules are transported extracellularly and gain access to its cognate receptors for autocrine and paracrine fashion and for signaling at distant sites reached through blood and lymphatic circulation systems. Intracellular pools of sphingosine 1-phosphate available for signaling are tightly regulated by three enzymes that include sphinosine kinase, S1P lyase and S1P phosphatase. Alterations in S1P levels as well as the enzymes involved in its synthesis and catabolism have been observed in many types of malignancy. These enzymes are being evaluated for their role in mediating cancer formation and progression, as well as their potential to serve as targets of anti-cancer therapeutics. In this review, the impact of sphingosine 1-phosphate, its cognate receptors, and the enzymes of sphingosine 1-phosphate metabolism on cell survival, apoptosis, autophagy, cellular transformation, invasion, angiogenesis and hypoxia in relation to cancer biology and treatment are discussed.
登录
查看更多内容
影响因子：
4.8
作者：
Bergelin, N.;Blom, T.;Toernquist, K.
通讯作者：
Toernquist, K.
影响因子：
5.6
作者：
Antunes Salinas, Natalia Regina;Fujiyama Oshima, Celina Tizuko;Bueno, Valquiria
通讯作者：
Bueno, Valquiria
影响因子：
4.1
作者：
Balthasar, Sonja;Samulin, Johanna;Tornquist, Kid
通讯作者：
Tornquist, Kid
DOI：
10.1016/j.bbrc.2006.02.070
发表时间：
2006-04-21
影响因子：
3.1
作者：
Akao, Y;Banno, Y;Nozawa, Y
通讯作者：
Nozawa, Y
影响因子：
15.9
作者：
Chae, SS;Paik, JH;Hla, T
通讯作者：
Hla, T