Evaluating the buffering vs. direct effects hypotheses of emotional social support on inflammatory markers: The Multi-Ethnic Study of Atherosclerosis
Evaluating the buffering vs. direct effects hypotheses of emotional social support on inflammatory markers: The Multi-Ethnic Study of Atherosclerosis
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DOI：
10.1016/j.bbi.2010.06.006
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发表时间：
2010-11-01
影响因子：
15.1
通讯作者：
Seeman, Teresa
中科院分区：
文献类型：
--
作者：
Mezuk, Briana;Roux, Ana V. Diez;Seeman, Teresa
社会支持与心血管疾病死亡率相关，然而，这种关系背后的生理机制尚未明确。本研究评估了社会支持与心血管风险相关的炎症标志物C-反应蛋白（CRP）、白细胞介素-6（IL-6）和纤维蛋白原的关系。较低社会支持与炎症直接相关，其次，较高的支持可以缓冲压力对炎症的影响。（N = 6814，53%女性，年龄45-84岁）我们评估了社会支持和压力与炎症的独立和相互作用的关联。通过情感社会支持指数测量社会支持。采用高灵敏度分析法分析空腹样本的血清CRP、IL-6和纤维蛋白原。（45-64岁和65-84岁），用于评估社会支持、压力和炎症之间的直接和缓冲关系。在双变量分析中，低社会支持与所有三种标志物的较高水平相关。低支持与较高的InCRP相关（B 0 15，95% Cl：001，030），而不是女性的高社会支持缓冲压力和CRP之间的关系，只有中年妇女（交互作用P = 0.042）总体而言，在这个相对健康的样本中，社会支持与炎症仅适度相关，这些关系因年龄和性别而异（C）2010 Elsevier Inc保留所有权利
Social support is associated with cardiovascular disease mortality, however, the physiologic mechanisms underlying this relationship remains unspecified This study evaluated the association of social support with inflammatory markers associated with cardiovascular risk C-reactive protein (CRP), interleukin-6 (IL-6), and fibrinogen We evaluated two competing models of the support-inflammation relationship first, that low social support is directly associated with inflammation, and second, that high support acts to buffer the effect of stress on inflammation Using data from the baseline interview of the Multi-Ethnic Study of Atherosclerosis (N = 6814, 53% female, age 45-84 years) we assessed the Independent and interacting associations of social support and stress with inflammation Social support was measured by the emotional social support index Stressors in multiple domains (work, family, finances, interpersonal) were assessed. Serum CRP, IL-6, and fibrinogen were analyzed from fasting samples using high-sensitivity assays Multivariate linear regression, including models stratified by gender and age group (45-64 and 65-84 years), was used to assess the direct and buffering relationships between social support, stress, and inflammation In bivariate analyses low social support was associated with higher levels of all three markers In adjusted models, low support was associated with higher InCRP (B 0 15, 95% Cl: 001, 0 30) among men but not women High social support buffered the relationship between stress and CRP among middle-aged women only (P for interaction 0 042) Overall, social support was only modestly associated with inflammation in this relatively healthy sample, and these relationships varied by age and gender (C) 2010 Elsevier Inc All rights reserved