Sex differences in intrusive memories following trauma
Sex differences in intrusive memories following trauma
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DOI：
10.1371/journal.pone.0208575
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发表时间：
2018-12-06
期刊：
影响因子：
3.7
通讯作者：
Felmingham, Kim L.
中科院分区：
文献类型：
--
作者：
Hsu, Chia-Ming K.;Kleim, Birgit;Felmingham, Kim L.
创伤后应激障碍（PTSD）的一个关键机制是增强情绪记忆巩固。最近在健康对照中的证据显示，女性在压力后的负面记忆巩固比男性要多。这项研究考察了PTSD患者的情绪记忆巩固情况，以及创伤暴露和非创伤对照，以检验女性PTSD患者情绪消极记忆巩固情况更强的假设。方法147名男性和女性（47名PTSD患者，49名创伤暴露对照组，51名非创伤对照组）完成了一项情绪记忆任务，他们观看了来自国际情感图像系统（IAPS）的消极、中性和积极图像。延迟回忆和侵入性记忆日记在两天后完成。结果与男性相比，女性表现出更强的记忆力，并报告了更多的负面侵入性记忆。一项性别群体互动效应显示，患有创伤后应激障碍的女性和有创伤经历的女性都比没有创伤经历的女性或男性报告了更多的侵入性记忆。结论本研究为创伤后应激障碍患者和创伤暴露史患者侵入性记忆的性别差异提供了初步证据。未来的研究应该包括性激素的测量，以进一步研究创伤暴露和创伤后应激障碍背景下记忆巩固的性别差异。
BackgroundA key mechanism thought to underlie Posttraumatic Stress Disorder (PTSD) is enhanced emotional memory consolidation. Recent evidence in healthy controls revealed that women have greater negative memory consolidation following stress relative to men. This study examined emotional memory consolidation in women and men with PTSD, and in trauma-exposed and non-trauma controls to test the hypothesis that emotionally negative memory consolidation would be greater in women with PTSD.MethodOne hundred and forty-seven men and women (47 with PTSD, 49 trauma-exposed controls, and 51 non-trauma controls) completed an emotional memory task where they looked at negative, neutral and positive images from the International Affective Picture System (IAPS). Delayed recall and an intrusive memory diary were completed two days later.ResultsWomen displayed greater recall, and reported more negative intrusive memories than men. A gender x group interaction effect showed that both women with PTSD and trauma-exposed women reported more intrusive memories than women without trauma exposure or men.ConclusionThis study provided preliminary evidence of sex differences in intrusive memories in those with PTSD as well as those with a history of trauma exposure. Future research should include measures of sex hormones to further examine sex differences on memory consolidation in the context of trauma exposure and PTSD.