CREUTZFELDT-JAKOB DISEASE IN A YOUNG-ADULT WITH IDIOPATHIC HYPOPITUITARISM - POSSIBLE RELATION TO THE ADMINISTRATION OF CADAVERIC HUMAN GROWTH-HORMONE
CREUTZFELDT-JAKOB DISEASE IN A YOUNG-ADULT WITH IDIOPATHIC HYPOPITUITARISM - POSSIBLE RELATION TO THE ADMINISTRATION OF CADAVERIC HUMAN GROWTH-HORMONE
复制标题
DOI：
10.1056/nejm198509193131206
复制
发表时间：
1985-01-01
影响因子：
158.5
通讯作者：
GRAVINA, RF
中科院分区：
文献类型：
--
作者：
KOCH, TK;BERG, BO;GRAVINA, RF
CreutzFeldt-Jakob病是一种传染性的中枢神经系统亚急性变性，通常被认为是老年人的疾病。1我们最近评估了一位20岁的男性患者，他患有特发性甲状腺功能减退症和胰岛素依赖型糖尿病，并发展为CreutzFeldt-Jakob病。从孩提时代起，他就接受了身体人体生长激素，以及胰岛素、甲状腺激素和最近的睾丸素。病例报告患者，20岁，被转诊到加州大学旧金山分校进行步态不稳定的评估。他的病史从婴儿期起就因多种脑下垂体激素缺乏以及胰岛素依赖型糖尿病而变得复杂。有人提出了垂体功能减退的建议。
CREUTZFELDT—JAKOB disease, a transmissible subacute degeneration of the central nervous system, is generally considered a disease of older adults.1We recently evaluated a 20-year-old man with idiopathic hypopituitarism and insulin-dependent diabetes mellitus in whom Creutzfeldt—Jakob disease developed. Since early childhood he had received cadaveric human growth hormone, as well as insulin, thyroid hormone, and more recently testosterone.Case ReportThe patient, a 20-year-old man, was referred to the University of California, San Francisco, for evaluation of progressive gait instability. His history was complicated by multiple deficiencies of pituitary hormones from infancy, as well as insulin-dependent diabetes mellitus. Hypopituitarism was suggested . . .