Parasite powerhouse: A review of the Toxoplasma gondii mitochondrion.
Parasite powerhouse: A review of the Toxoplasma gondii mitochondrion.
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DOI：
10.1111/jeu.12906
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发表时间：
2022-11
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
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弓形虫是顶复门的一员，顶复门是一组单细胞真核寄生虫，在世界各地引起显著的人类发病率和死亡率。刚地弓形虫有两个内共生起源的细胞器：一个非光合作用的质体，称为顶质体，和一个来自α变形菌的古老吞噬的单胞体。由于对顶质体的新奇性感到兴奋，弓形虫的寄生虫在一定程度上被忽视了大约二十年。然而，最近的研究表明，该蛋白是apicomplexan特异性生物学的重要枢纽。新技术的发展，如冷冻电子显微镜，复合体分析和下一代测序，导致了线粒体研究的复兴。这篇综述将涵盖目前已知的弓形虫幼虫的关键特征，从基因组到蛋白质输入机制和生化途径。特别关注的是线粒体的功能，从哺乳动物宿主的分歧显着，沿着讨论这个重要的细胞器作为药物靶点。
Toxoplasma gondii is a member of the apicomplexan phylum, a group of single‐celled eukaryotic parasites that cause significant human morbidity and mortality around the world. T. gondii harbors two organelles of endosymbiotic origin: a non‐photosynthetic plastid, known as the apicoplast, and a single mitochondrion derived from the ancient engulfment of an α‐proteobacterium. Due to excitement surrounding the novelty of the apicoplast, the T. gondii mitochondrion was, to a certain extent, overlooked for about two decades. However, recent work has illustrated that the mitochondrion is an essential hub of apicomplexan‐specific biology. Development of novel techniques, such as cryo‐electron microscopy, complexome profiling, and next‐generation sequencing have led to a renaissance in mitochondrial studies. This review will cover what is currently known about key features of the T. gondii mitochondrion, ranging from its genome to protein import machinery and biochemical pathways. Particular focus will be given to mitochondrial features that diverge significantly from the mammalian host, along with discussion of this important organelle as a drug target.
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影响因子：
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作者：
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DOI：
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