Role of testosterone in the sexual dimorphism of adrenal activity at puberty in the guinea-pig.
Role of testosterone in the sexual dimorphism of adrenal activity at puberty in the guinea-pig.
复制标题
睾酮在豚鼠青春期肾上腺活动性二态性中的作用。
作者：
A. El Hani;M. Dalle;P. Delost
青春期豚鼠肾上腺皮质活动出现两性二态性，雄性豚鼠血浆皮质醇水平和结合率低于雌性，皮质醇代谢清除率（MCR）高于雌性。雌性豚鼠的性腺切除术没有改变调节肾上腺活性的参数值。雄性豚鼠的阉割通过增加转皮质素对皮质醇的结合能力和降低皮质醇MCR来引起血浆皮质醇水平升高。从第24天开始用睾酮治疗雌性动物，在第50天血浆皮质醇水平下降，之后皮质醇的转皮质素结合能力降低，同时皮质醇MCR增加。此外，去势雄性动物对应激的肾上腺反应高于对照组，睾酮给药雌性动物对应激的肾上腺反应低于对照组。睾酮似乎是负责青春期豚鼠肾上腺活动性二型性的激素。
Sexual dimorphism in adrenal activity appeared during the pubertal period of the guinea-pig with plasma levels and binding of cortisol lower in male guinea-pigs compared with female, and metabolic clearance rate (MCR) of cortisol higher in male than in female animals. Gonadectomy of female guinea-pigs did not change the values of the parameters regulating adrenal activity. Castration of male guinea-pigs caused a rise in plasma cortisol levels by increasing the binding capacity of transcortin for cortisol and by decreasing cortisol MCR. Treatment of females with testosterone from day 24 produced a drop on day 50 in plasma cortisol levels following a decreased binding capacity of transcortin for cortisol and at the same time as cortisol MCR increased. Furthermore, the adrenal response to stress was higher in castrated than in control males and lower in testosterone-treated females compared with control females. Testosterone appeared to be the hormone responsible for sexual dimorphism in adrenal activity in the pubertal guinea-pig.