Synthesis of ring-contracted derivatives of erythromycin
Synthesis of ring-contracted derivatives of erythromycin
复制标题
红霉素缩环衍生物的合成
DOI：
10.1021/jo00228a038
复制
发表时间：
1987
影响因子：
3.6
通讯作者：
J. Paschal
中科院分区：
文献类型：
--
作者：
H. Kirst;J. A. Wind;J. Paschal
最近的出版物报道了利用14元大环内酯类抗生素作为前体合成1和分离2一些12元大环内酯类衍生物。此类化合物代表了合成用于临床和/或兽医学的潜在有用的抗生素的新方法。很少有12元大环内酯类化合物作为天然产物被分离出来，并且在该类化合物中很少进行结构修饰。3本文报道了几种红霉素缩环衍生物的合成。在我们的手稿提交后，发表了一份关于红霉素转内酯化的报告，其中描述了与我们的一些工作类似的结果。4
Recent publications have reported the synthesis1 and isolation2 of some 12-membered macrolide derivatives utilizing 14-membered macrolide antibiotics as precursors. Such compounds represent a new approach to the synthesis of potentially useful antibiotics for clinical and/or veterinary medicine. Very few12-membered macrolides have been isolated as natural products and very little structural modification has been performed within this class. 3 In this paper, we report our synthetic efforts to-ward several ring-contracted derivatives of erythromycin. After submission of our manuscript, a report concerning translactonization of erythromycins was published in which results analogous to some of our work were described. 4