Application of Transcranial Direct Current Stimulation in Neurorehabilitation: The Modulatory Effect of Sleep.
Application of Transcranial Direct Current Stimulation in Neurorehabilitation: The Modulatory Effect of Sleep.
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DOI：
10.3389/fneur.2016.00054
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发表时间：
2016
影响因子：
3.4
通讯作者：
Sterr A
中科院分区：
文献类型：
--
作者：
Ebajemito JK;Furlan L;Nissen C;Sterr A
睡眠障碍和神经系统疾病之间的关系通常是相互影响的，神经系统症状会加剧睡眠障碍，而睡眠不佳会加剧神经系统疾病。动物和人类研究进一步表明，睡眠中断不仅会恶化单一的神经症状，还可能导致长期的负面结果。这表明睡眠可能在神经康复和恢复中发挥重要作用。我们进一步提出，睡眠不仅可以改变行为治疗的功效，还可以改变可塑性增强的辅助神经刺激方法，例如经颅直流电刺激（tDCS）。目前，睡眠在神经康复和神经刺激领域很少受到关注。在这篇综述中，我们汇集了这两个研究领域的证据，强调睡眠是应用 tDCS 作为主要或辅助康复干预时需要考虑的一个重要参数。
The relationship between sleep disorders and neurological disorders is often reciprocal, such that sleep disorders are worsened by neurological symptoms and that neurological disorders are aggravated by poor sleep. Animal and human studies further suggest that sleep disruption not only worsens single neurological symptoms but may also lead to long-term negative outcomes. This suggests that sleep may play a fundamental role in neurorehabilitation and recovery. We further propose that sleep may not only alter the efficacy of behavioral treatments but also plasticity-enhancing adjunctive neurostimulation methods, such as transcranial direct current stimulation (tDCS). At present, sleep receives little attention in the fields of neurorehabilitation and neurostimulation. In this review, we draw together the strands of evidence from both fields of research to highlight the proposition that sleep is an important parameter to consider in the application of tDCS as a primary or adjunct rehabilitation intervention.