Effect of chewing gums containing xylitol or probiotic bacteria on salivary mutans streptococci and lactobacilli
Effect of chewing gums containing xylitol or probiotic bacteria on salivary mutans streptococci and lactobacilli
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DOI：
10.1007/s00784-007-0129-9
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发表时间：
2007-12-01
影响因子：
3.4
通讯作者：
Twetman, S.
中科院分区：
文献类型：
--
作者：
Caglar, E.;Kavaloglu, S. C.;Twetman, S.
目的是评价木糖醇和益生菌口香糖对唾液变形链球菌（MS）和乳酸杆菌（LB）的影响。材料由80名健康的年轻人（21-24岁）组成，他们在知情同意后自愿参加。他们被随机分配到四个平行研究组：A，益生菌口香糖组；B，木糖醇胶组；C、益生菌+木糖醇胶组；D，安慰剂口香糖组。每日饭后服用3次牙龈，干预期为3周。益生菌胶含有两株罗伊氏乳杆菌(ATCC 55730剂量为1 × 10(8) CFU/gum和ATCC PTA 5289剂量为1 × 10(8) CFU/gum)，每个木糖醇胶颗粒含有约1.0 g木糖醇作为单一甜味剂。收集受刺激的全唾液预处理和后处理样品，并使用椅侧试剂盒对MS和LB进行定量。干预后A、B组唾液MS与基线比较，均有统计学意义（p < 0.05）。c组有类似但不显著的趋势，各组均未见唾液LB改变。综上所述，每天咀嚼含有益生菌或木糖醇的牙龈可显著降低唾液MS水平。然而，益生菌和木糖醇胶的组合似乎并没有增强这种效果。
The aim was to evaluate the effect of xylitol and probiotic chewing gums on salivary mutans streptococci (MS) and lactobacilli (LB). The material consisted of 80 healthy young adults (21-24 years) who volunteered after informed consent. They were assigned by random into one of four parallel study groups: A, probiotic gum group; B, xylitol gum group; C, probiotic + xylitol gum group; and D, placebo gum group. The gums were taken three times daily after meals, and the intervention period was 3 weeks. The probiotic gums contained two strains of Lactobacilli reuteri (ATCC 55730 at a dose of 1 x 10(8) CFU/gum and ATCC PTA 5289 at a dose of 1 x 10(8) CFU/gum), and each pellet of the xylitol gum contained approximate to 1.0 g xylitol as single sweetener. Pretreatment and posttreatment samples of stimulated whole saliva were collected and quantified for MS and LB with chair-side kits. A statistically significant reduction (p < 0.05) of salivary MS was displayed in group A and B after the intervention when compared with baseline. A similar but nonsignificant tendency was seen in group C. No alterations of salivary LB was demonstrated in any group. In conclusion, daily chewing on gums containing probiotic bacteria or xylitol reduced the levels of salivary MS in a significant way. However, a combination of probiotic and xylitol gums did not seem to enhance this effect.