Animal modeling of poststroke seizures and epilepsy: 5-year update.
Animal modeling of poststroke seizures and epilepsy: 5-year update.
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DOI：
10.1111/j.1535-7511.2007.00211.x
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发表时间：
2007-11-01
影响因子：
3.6
通讯作者：
Kelly, Kevin M
中科院分区：
文献类型：
--
作者：
Kelly, Kevin M
多年来，许多临床和流行病学研究都描述了中风后癫痫发作和癫痫。相比之下，在受伤的大脑中发生的病理生理事件，建立卒中后癫痫发生和癫痫尚不清楚。然而，在过去的几年里，动物模型在提高对与中风后早期和晚期癫痫发作相关的进行性生化、解剖和生理变化的理解方面取得了重大进展。对脑卒中后癫痫发作和癫痫的动物研究进行综述。
Poststroke seizures and epilepsy have been described in numerous clinical and epidemiological studies over many years. In contrast, the pathophysiological events occurring in injured brain that establish poststroke epileptogenesis and epilepsy are not known. However, in the last several years, animal modeling has made significant inroads toward an improved understanding of the progressive biochemical, anatomical, and physiological changes associated with both early and late seizures following stroke. A review of animal studies of poststroke seizures and epilepsy is presented.