Effect of laparoscopic excision of endometriomas on ovarian reserve: serial changes in the serum antimullerian hormone levels
Effect of laparoscopic excision of endometriomas on ovarian reserve: serial changes in the serum antimullerian hormone levels
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DOI：
10.1016/j.fertnstert.2012.03.027
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发表时间：
2012-06-01
影响因子：
6.7
通讯作者：
Koyuncuoglu, Meral
中科院分区：
文献类型：
--
作者：
Celik, Hale Goksever;Dogan, Erbil;Koyuncuoglu, Meral
目的：目的探讨腹腔镜下子宫肌瘤剥除术对血清抗苗勒管激素（AMH）的影响及其与临床病理因素的相关性。设计：前瞻性研究。地点：大学医院。患者：65名女性子宫肌瘤患者。干预：所有患者均接受腹腔镜下子宫肌瘤剥除术。分别于术前、术后6周和6个月测定血清AMH、FSH、LH、E-2和窦卵泡计数（AFC）。结果：术后6个月血清AMH水平明显下降（61%），术后6个月血清FSH、LH、E-2、AFC水平明显下降（61%）。FSH水平在第6周时显著升高，但在第6个月时恢复正常。AFC在第6周和第6个月显著增加。AMH水平下降在囊肿患者中更为明显
Objective: To investigate the effect of laparoscopic endometrioma stripping on serum antimullerian hormone (AMH) and the correlation between the clinicopathologic factors.Design: Prospective study.Setting: University hospital.Patient(s): Sixty-five women with endometriomas.Intervention(s): All patients underwent laparoscopic cystectomy. Serum AMH, FSH, LH, E-2, and antral follicle count (AFC) were measured preoperatively, at 6 weeks, and at 6 months postoperatively. Specimens were analyzed histopathologically.Main Outcome Measure(s): The primary end point was to assess the ovarian reserve damage based on alterations of AMH and the secondary end point was to detect the changes in FSH, LH, E-2, and AFC.Result(s): Serum AMH decreased significantly at the sixth month (61%) postoperatively. The FSH level increased significantly at the sixth week, but returned to normal at the sixth month. The AFC increased significantly at the sixth week and at the sixth month. The AMH level decrease was more evident in patients with the cyst