Association of educational achievement with pulsatile arterial diameter change of the common carotid artery - The atherosclerosis risk in communities (ARIC) study, 1987-1992
Association of educational achievement with pulsatile arterial diameter change of the common carotid artery - The atherosclerosis risk in communities (ARIC) study, 1987-1992
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DOI：
10.1093/aje/152.7.617
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发表时间：
2000-10-01
影响因子：
5
通讯作者：
Tyroler, HA
中科院分区：
文献类型：
--
作者：
Din-Dzietham, R;Liao, DP;Tyroler, HA
在社区动脉粥样硬化风险 (ARIC) 研究中，教育程度与颈总动脉内膜中层厚度呈强烈负相关。作者通过评估教育与颈总动脉弹性的横断面关联，扩展了 ARIC 对临床前动脉粥样硬化的研究。这项研究包括 10,091 名年龄在 45-64 岁之间、没有临床冠心病和中风/短暂性脑缺血发作的黑人和白人男性和女性。动脉弹性通过来自锁相回波跟踪的脉动动脉直径变化（PADC）进行评估。 PADC 越小，动脉越僵硬。教育分为小学、未毕业高中、毕业高中、职业学校、一些大学和研究生/专业学校。 PADC 与教育程度直接相关。根据年龄、身高、舒张直径、收缩压、脉压（线性和平方）、种族、性别和吸烟状况调整后，连续高等教育阶层的平均 PADC 为 402（标准误差 (SE) 5）、403 (SE 4)、407 (SE 3)、413 (SE 4)、416 (SE 2) 和 417 (SE 4) mu米（p = 0.007）。据作者所知，这是第一次报道这种关联。如果动脉扩张受损先于动脉粥样硬化过程中的动脉壁增厚，正如最近对内皮功能障碍的研究表明的那样，这些结果表明，低社会经济地位可能与早期动脉病理生理变化有关，这种效应似乎是由已确定的心血管疾病危险因素介导的。
Education is strongly inversely associated with common carotid artery intima-media thickness in the Atherosclerosis Risk in Communities (ARIC) Study. The authors extended the ARIC study of preclinical atherosclerosis by evaluating the cross-sectional association of education with common carotid artery elasticity. This study included 10,091 Black and White men and women aged 45-64 years who were free of clinical coronary heart disease and stroke/transient ischemic attack. Arterial elasticity was assessed by pulsatile arterial diameter change (PADC), derived from phase-locked echo-tracking. The smaller the PADC, the stiffer the artery. Education was categorized into grade school, high school without graduation, high school with graduation, vocational school, some college, and graduate/professional school. PADC was directly associated with educational attainment. The mean PADCs, adjusted for age, height, diastolic diameter, systolic blood pressure, pulse pressure (linear and squared), ethnicity, gender, and smoking status, in successively higher education strata were 402 (standard error (SE) 5), 403 (SE 4), 407 (SE 3), 413 (SE 4), 416 (SE 2), and 417 (SE 4) mu m (p = 0.007). To the authors' knowledge, this is the first time such an association has been reported. If arterial dilation impairment precedes arterial wall thickening in the atherosclerotic process, as recent studies on endothelial dysfunction suggest, these results indicate that low socioeconomic status may be associated with early arterial pathophysiologic changes-an effect that appears to be mediated by established cardiovascular disease risk factors.