Coordination of multiple joints increases bilateral connectivity with ipsilateral sensorimotor cortices.
Coordination of multiple joints increases bilateral connectivity with ipsilateral sensorimotor cortices.
复制标题
多个关节的协调增加了与同侧感觉运动皮层的双边连接。
DOI：
10.1016/j.neuroimage.2019.116344
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发表时间：
2020
期刊：
影响因子：
5.7
通讯作者：
Yao,Jun
中科院分区：
文献类型：
--
作者：
Wilkins,KevinB;Yao,Jun
尽管日常生活中的大多数活动都需要近端和远端关节的同时协调，但此类运动期间的运动准备尚未得到充分研究。之前的运动准备结果主要集中在手/手指的运动上。对于简单的手/手指运动，结果发现这种运动通常主要引起对侧运动皮层的活动。然而，增加手指运动的复杂性，例如在远端连续手指按压任务期间，会导致同侧资源的额外募集。有人认为，同侧半球的参与对于远端关节的时间协调至关重要。当前研究的目的是检查与简单的远端运动（例如张开手）相比，增加多个关节（近端和远端）的同时协调是否会导致运动准备过程中与同侧感觉运动皮层的耦合类似增加。为了测试这种可能性，12 名健康人参加了一项高密度脑电图实验，他们在机器人设备上进行张手或同时张手，同时抬起肩膀。我们使用动态因果模型量化了这两项任务的感觉运动皮层的同频和跨频皮层耦合。张开手和在肩部抬起时同时张开手都会引发从次级运动区域到对侧半球内的初级运动皮层（仅在β带）以及从同侧初级运动皮层的耦合。然而，通过将手张开并举起肩膀来增加任务复杂性，也会导致同侧半球内的交叉频率耦合增加，包括θ、β和伽马频率，以及初级运动皮层和前运动皮层之间的半球间耦合的耦合频率的变化。这些发现表明，增加近端和远端关节之间的关节协调需求会导致与同侧半球的沟通增加，正如之前在远端顺序手指任务中观察到的那样。
Although most activities of daily life require simultaneous coordination of both proximal and distal joints, motor preparation during such movements has not been well studied. Previous results for motor preparation have focused on hand/finger movements. For simple hand/finger movements, results have found that such movements typically evoke activity primarily in the contralateral motor cortices. However, increasing the complexity of the finger movements, such as during a distal sequential finger-pressing task, leads to additional recruitment of ipsilateral resources. It has been suggested that this involvement of the ipsilateral hemisphere is critical for temporal coordination of distal joints. The goal of the current study was to examine whether increasing simultaneous coordination of multiple joints (both proximal and distal) leads to a similar increase in coupling with ipsilateral sensorimotor cortices during motor preparation compared to a simple distal movement such as hand opening. To test this possibility, 12 healthy individuals participated in a high-density EEG experiment in which they performed either hand opening or simultaneous hand opening while lifting at the shoulder on a robotic device. We quantified within- and cross-frequency cortical coupling across the sensorimotor cortex for the two tasks using dynamic causal modeling. Both hand opening and simultaneous hand opening while lifting at the shoulder elicited coupling from secondary motor areas to primary motor cortex within the contralateral hemisphere exclusively in the beta band, as well as from ipsilateral primary motor cortex. However, increasing the task complexity by combining hand opening while lifting at the shoulder also led to an increase in cross-frequency coupling within the ipsilateral hemisphere including theta, beta, and gamma frequencies, as well as a change in the coupling frequency of the interhemispheric coupling between the primary motor and premotor cortices. These findings demonstrate that increasing the demand of joint coordination between proximal and distal joints leads to increases in communication with the ipsilateral hemisphere as previously observed in distal sequential finger tasks.