Gemstone spectral imaging in lung cancer: A preliminary study.
Gemstone spectral imaging in lung cancer: A preliminary study.
复制标题
宝石光谱成像在肺癌中的初步研究
DOI：
10.1097/md.0000000000011170
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发表时间：
2018-07
期刊：
影响因子：
1.6
通讯作者：
Jiang H
中科院分区：
文献类型：
--
作者：
Jia Y;Xiao X;Sun Q;Jiang H
本研究旨在评价宝石光谱成像（GSI）在肺癌多参数定量测量中的应用。方法回顾性分析30例肺癌患者的GSI模式胸部增强CT扫描。GSI查看器用于图像显示和数据分析。测量最佳能量值、40 keV、70 keV和最佳能级下的CT值、光谱曲线斜率、有效原子序数（Zeff）、感兴趣区域的碘浓度（IC）和水浓度（WC），并采用统计学方法进行分析。在平扫、动脉期和静脉期获得最佳对比噪声比的最佳能量值分别为62.2 ± 5.38 keV、50.63 ± 3.84 keV和52.5 ± 3.7 keV。 每个扫描时相不同能量水平的CT值有显著差异（P = 0.033）。 在40 ~ 70 keV、40 ~ 100 keV和40 ~ 140 keV之间的谱线斜率值有显著性差异（P <0.001）。 在每个能量水平间隔，动脉相和静脉相之间的斜率没有观察到显著差异。Zeff在平扫、动脉期和静脉期分别为7.75 ± 0.15、8.38 ± 0.37和8.38 ± 0.30。 增强扫描中IC、标准化IC和Zeff之间呈正相关。GSI的多参数可用于肺肿瘤病变的评价。不同的参数相互关联，并提供多种定性和定量信息。
The present study aimed to evaluate the application of gemstone spectral imaging (GSI) for multi-parameter quantitative measurement in lung cancer. The study retrospectively enrolled 30 patients with lung cancer who underwent chest contrast enhanced CT scan with GSI mode. The GSI viewer was used for image display and data analysis. Optimal energy value, CT values at 40 keV, 70 keV and optimal energy level, spectral curve slope, effective atomic number (Zeff), iodine concentration (IC), and water concentration (WC) at the region of interest were measured and analyzed by statistical methods. The optimal energy value for optimal contrast-to-noise ratio on plain scan, arterial phase and venous phase was 62.2 ± 5.38 keV, 50.63 ± 3.84 keV, and 52.5 ± 3.7 keV, respectively. There were significant differences in CT values at different energy levels on each scan phase (P = .033). The spectral curve slope values among 40 to 70 keV, 40 to 100 keV, and 40 to 140 keV were significantly different (P < .001). No significant difference with the slope between arterial phase and venous phase at each energy level interval was observed. Zeff on plain scan, arterial phase, and venous phase was 7.75 ± 0.15, 8.38 ± 0.37, and 8.38 ± 0.30, respectively. Positive correlation was observed among IC, normalized IC, and Zeff on enhanced scan. Multiparameter of GSI can be used for lung tumor lesion evaluation. Different parameters were correlated and provide multiple qualitative and quantitative information together.