Fray, a Drosophila serine/threonine kinase homologous to mammalian PASK, is required for axonal ensheathment
Fray, a Drosophila serine/threonine kinase homologous to mammalian PASK, is required for axonal ensheathment
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DOI：
10.1016/s0896-6273(00)00154-9
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发表时间：
2000-12-01
期刊：
影响因子：
16.2
通讯作者：
Keshishian, H
中科院分区：
文献类型：
--
作者：
Leiserson, WM;Harkins, EW;Keshishian, H
Fray是果蝇外周胶质细胞表达的一种丝氨酸/苏氨酸激酶，其功能是正常轴突嵌套所必需的。Null fray突变体在幼虫发育早期死亡，神经严重肿胀，轴突无血循环。这种表型与成鞘胶质细胞不能正确包裹外周轴突有关。当在磨损突变体的鞘胶质细胞中表达磨损cDNA时，正常的神经形态得以恢复。Fray属于一个新的Ser/Thr激酶家族，PF激酶，其最近的亲戚是PAK激酶。用PASK拯救果蝇突变表型，弗雷的大鼠同源物，证明了这些蛋白质之间的功能同源性，并表明弗雷信号通路是广泛保守的。
Fray is a serine/threonine kinase expressed by the peripheral glia of Drosophila, whose function is required for normal axonal ensheathment. Null fray mutants die early in larval development and have nerves with severe swelling and axonal defasciculation. The phenotype is associated with a failure of the ensheathing glia to correctly wrap peripheral axons. When the fray cDNA is expressed in the ensheathing glia of fray mutants, normal nerve morphology is restored. Fray belongs to a novel family of Ser/Thr kinases, the PF kinases, whose closest relatives are the PAK kinases. Rescue of the Drosophila mutant phenotype with PASK, the rat homolog of Fray, demonstrates a functional homology among these proteins and suggests that the Fray signaling pathway is widely conserved.