Bone response to plasma-sprayed hydroxyapatite and radiofrequency-sputtered calcium phosphate implants in vivo.
Bone response to plasma-sprayed hydroxyapatite and radiofrequency-sputtered calcium phosphate implants in vivo.
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发表时间：
2002-07
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通讯作者：
J. Ong;K. Bessho;D. Carnes
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作者：
J. Ong;K. Bessho;D. Carnes
目的探讨射频溅射钙磷涂层对钛种植体骨-种植体界面结合强度和骨接触长度的影响。材料与方法将柱状溅射、帽状涂层和等离子喷涂羟基磷灰石(HA)涂层种植体(直径4.0 mm、长8 mm)植入犬下颌骨。溅射的帽状涂层植入物中有一半是经过热处理的。结果种植体植入12周后，溅射帽状涂层、溅射帽状涂层热处理和对照等离子喷涂羟基磷灰石涂层种植体的平均界面强度差异无统计学意义。组织形态计量学评价表明，等离子喷涂HA涂层种植体与溅射帽涂层种植体的骨接触长度百分比相似，且显著大于溅射帽涂层热处理种植体。下颌骨不同种植部位之间的最终界面强度和骨接触长度百分比没有观察到差异。讨论这项研究的结果，结合以前的研究结果，表明一旦实现早期骨整合，薄帽涂层的生物降解不会损害骨涂层-种植体固定，也不会影响对涂层种植体表面的骨反应。结论界面强度和组织形态计量学数据表明，采用溅射工艺制备的帽状涂层具有与等离子喷涂羟基磷灰石涂层相似的骨响应。
PURPOSE The objective of this study was to evaluate the effect of radiofrequency- (RF) sputtered calcium phosphate (CaP) coating of titanium implants on bond strength at the bone-implant interface and percent bone contact length. MATERIALS AND METHODS Cylindric sputtered CaP-coated and plasma-sprayed hydroxyapatite- (HA) coated implants (4.0 mm diameter and 8 mm length) were implanted in dog mandibles. Half the sputtered CaP-coated implants were heat-treated. RESULTS Twelve weeks after implant placement, no statistical differences in the mean ultimate interfacial strengths were observed between as-sputtered CaP-coated, sputtered CaP-coated heat-treated, and control plasma-sprayed HA-coated implants. Histomorphometric evaluation indicated that the percent bone contact lengths for the plasma-sprayed HA-coated implants and the as-sputtered CaP-coated implants were similar and significantly greater than that for the sputtered CaP-coated heat-treated implants. Differences in the ultimate interfacial strength and percent bone contact length between different implant sites in the mandible were not observed. DISCUSSION The results of this study, considered together with the results of previous studies, suggest that once early osseointegration is achieved, biodegradation of the thin CaP coatings is not detrimental to bone-coating-implant fixation, and does not compromise bone responses to the coated implant surfaces. CONCLUSION The interfacial strength and histomorphometric data suggest that the CaP coatings applied using the sputtering process produce bone responses similar to those of HA coatings applied using plasma spraying.