Presystemic drug elimination.
Presystemic drug elimination.
复制标题
系统前药物消除。
DOI：
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发表时间：
1979
影响因子：
12.5
通讯作者：
D. Shand
中科院分区：
文献类型：
--
作者：
P. Routledge;D. Shand
大量化合物的系统前消除已明确确定，并且是生物利用度降低的常见且不可避免的原因。肝脏、肠和肺已被确定为有助于这种效应的潜在器官，但只有肝脏才有足够的数据可用于综合分析。显然需要更多有关肠道和肺部代谢的信息。然而，已经存在简单的动力学分析方法来评估这些器官在系统前消除中的相对重要性，特别是与可能发生的吸收前和吸收后类型的消除有关。
The presystemic elimination of a large number of compounds is clearly established and represents a common and unavoidable cause of reduced bioavailability. The liver, intestine, and lungs have been identified as potential organs contributing to this effect but only in the case of the liver are sufficient data available for comprehensive analysis. More information on intestinal and pulmonary metabolism is clearly needed. Simple methods of kinetic analysis already exist, however, to assess the relative importance of these organs in presystemic elimination, especially in relation to the pre- and postabsorptive types of elimination that may occur.