Elevated levels of platelet microparticles are associated with disease activity in rheumatoid arthritis
Elevated levels of platelet microparticles are associated with disease activity in rheumatoid arthritis
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DOI：
10.1002/art.10312
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发表时间：
2002-06-01
影响因子：
--
通讯作者：
van de Laar, MAFJ
中科院分区：
文献类型：
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作者：
Knijff-Dutmer, EAJ;Koerts, J;van de Laar, MAFJ
目标。血小板参与各种血栓形成事件，通常是通过血小板衍生微粒(PMP)。很可能，血小板也参与了炎症。由于炎症过程在类风湿关节炎(RA)中起核心作用，我们试图确定这种疾病中是否存在PMPs。这项描述性的横断面研究包括19名RA患者和10名健康对照。其中9例为活动期RA(血沉>28 mm/h和/或C反应蛋白>28 mg/L，>9个关节疼痛，>6个肿胀关节)，10例为非活动期疾病(血沉<27 mm/h，C反应蛋白：527 mg/L，关节无压痛，关节无肿胀)。血小板计数采用细胞计数法，PMP计数采用流式细胞仪。3组患者的血小板计数相似。但类风湿关节炎患者血浆PMPs水平显著高于健康对照组(中位数616vs118×10(6)/L，P=0.005)。活动期RA患者的PMP水平高于非活动期RA患者(中位数为2,104比504×10(6)/升；P>；0.05)。PMP水平与疾病活动性呈正相关(r=0.67，P=0.05)。PMP与RA相关，PMP水平与疾病活动性相关。因此，血小板可能通过PMPs参与类风湿关节炎的炎症过程。鉴于PMPs在心血管疾病中的重要性，这可能是RA心血管发病率和死亡率增加的原因之一。
Objective. Platelets are involved in various thrombotic events, often by means of platelet-derived microparticles (PMPs). It is likely that platelets are also involved in inflammation. Because inflammatory processes play a central role in rheumatoid arthritis (RA), we sought to determine whether PMPs are present in this disease.Methods. This descriptive, cross-sectional study included 19 RA patients and 10 healthy controls. Nine of the patients had active RA (erythrocyte sedimentation rate [ESR] greater than or equal to28 mm/hour and/or C-reactive protein [CRP] level greater than or equal to28 mg/liter, greater than or equal to9 painful joints, and greater than or equal to6 swollen joints), and 10 had inactive disease (ESR less than or equal to27 mm/hour, CRP :527 mg/liter, no tender joints, and no swollen joints). Platelet counts and PMP numbers were determined using cell counter and flow cytometry, respectively.Results. Platelet counts in the 3 groups were similar. However, levels of PMPs in RA patients were significantly higher than those in healthy controls (median 616 versus 118 x 10(6)/liter, P = 0.005). PMP levels were higher in patients with active RA than in those with inactive RA (median 2,104 versus 504 x 10(6)/liter; P > 0.05). Moreover, PMP levels correlated with disease activity (r = 0.67, P = 0.05).Conclusion. PMPs are associated with RA, and PMP levels are correlated with disease activity. Thus, platelets probably play a part in the inflammatory process of RA by means of PMPs. Given the importance of PMPs in cardiovascular diseases, this may be one reason for the enhanced cardiovascular morbidity and mortality in RA.