Effects of acute preload reduction on myocardial velocity during isovolumic contraction and myocardial acceleration in pediatric patients
Effects of acute preload reduction on myocardial velocity during isovolumic contraction and myocardial acceleration in pediatric patients
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DOI：
10.1007/s00246-005-0877-8
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发表时间：
2006-02-01
影响因子：
1.6
通讯作者：
Takada, G
中科院分区：
文献类型：
--
作者：
Duan, YQ;Harada, K;Takada, G
我们评价了急性前负荷减少和下腔静脉（IVC）闭塞对儿童患者收缩期（Sa）、早期（Ea）和晚期（Aa）舒张期、等容收缩（IVV）和心肌加速度（IVA）的影响。共研究了22名患者（5 +/- 3年）：9名川崎病患者（4 +/- 3年）、8名房间隔缺损和右心室（RV）容量超负荷患者（6 +/- 3年）以及5名患者（5 +/- 4年）患有肺动脉狭窄和右心室压力超负荷。在四腔心切面上用TDI记录右室游离壁基底部的Sa、Ea、Aa、IVV。通过将IVV除以从IVV开始到该波达到峰值速度的时间间隔来计算IVA。在各组中，IVC阻塞导致峰值Sa、峰值Ea和峰值Aa显著降低（p < 0.05）。然而，IVV和IVA在急性前负荷减少期间没有变化。本研究证明了急性前负荷降低对TDI速度的影响。与峰Sa、峰Ea和峰Aa相反，IVV和IVA在生理范围内不受前负荷的影响。
We evaluated the effects of acute preload reduction with inferior vena cava (IVC) occlusion on myocardial velocities during systole ( Sa), early ( Ea) and late (Aa) diastole, isovolumic contraction (IVV), and myocardial acceleration (IVA) measured by tissue Doppler imaging (TDI) in pediatric patients. A total of 22 patients ( 5 +/- 3 years) were studied: 9 patients ( 4 +/- 3 years) with Kawasaki disease, 8 patients ( 6 +/- 3 years) with atrial septal defect and right ventricular ( RV) volume overload, and 5 patients ( 5 +/- 4 years) with pulmonary stenosis and RV pressure overload. Using TDI, Sa, Ea, Aa, IVV were recorded at the base of the RV free wall from a four-chamber view. IVA was calculated by dividing IVV by the time interval from onset of IVV to the time at peak velocity of this wave. In each group, IVC occlusion caused significant decreases in peak Sa, peak Ea, and peak Aa ( p < 0.05). However, IVV and IVA did not change during acute preload reduction. This study demonstrated the effects of acute preload reduction on TDI velocities. In contrast to peak Sa, peak Ea, and peak Aa, IVV and IVA were unaffected by preload within a physiological range.