Morphometric brain abnormalities in boys with conduct disorder
Morphometric brain abnormalities in boys with conduct disorder
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DOI：
10.1097/chi.0b013e3181676545
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发表时间：
2008-05-01
影响因子：
13.3
通讯作者：
Herpertz-Dahlmann, Beate
中科院分区：
文献类型：
--
作者：
Huebner, Thomas;Vloet, Timo D.;Herpertz-Dahlmann, Beate
目的：早发性品行障碍(CD)儿童是发展成反社会人格障碍的高危人群。虽然已经有几项关于反社会人格障碍成年人的形态测量差异的神经成像研究，但对患有CD的男孩的结构性大脑异常知之甚少。方法：采用磁共振成像和基于体素的形态计量学方法，对23例12~17岁CD患儿(其中17例合并注意缺陷/多动障碍)的灰质体积进行检测，并与年龄和智商相匹配的对照组进行比较。结果：与健康对照组相比，临床组平均灰质体积缩小6%。与对照组相比，CD组左侧眶前区和双侧颞叶(包括左侧杏仁核和海马体)灰质体积减少。临床组的回归分析表明，多动/冲动症状与额顶和颞叶皮质广泛的灰质异常呈负相关。相比之下，CD的症状主要与边缘脑结构中的灰质减少有关。结论：数据表明，患有CD并伴有注意力缺陷/多动障碍的男孩在额叶边缘区域表现出类似结构性脑缺陷的大脑异常，这通常在有反社会行为的成年人中观察到。
Objective: Children with the early-onset type of conduct disorder (CD) are at high risk for developing an antisocial personality disorder. Although there have been several neuroimaging studies on morphometric differences in adults with antisocial personality disorder, little is known about structural brain aberrations in boys with CD. Method: Magnetic resonance imaging and voxel-based morphometry were used to assess abnormalities in gray matter volumes in 23 boys ages 12 to 17 years with CD (17 comorbid for attention-deficit/hyperactivity disorder) in comparison with age- and IQ-matched controls. Results: Compared with healthy controls, mean gray matter volume was 6% smaller in the clinical group. Compared with controls, reduced gray matter volumes were found in the left orbitofrontal region and bilaterally in the temporal lobes, including the amygdala and hippocampus on the left side in the CD group. Regression analyses in the clinical group indicated an inverse association of hyperactive/impulsive symptoms and widespread gray matter abnormalities in the frontoparietal and temporal cortices. By contrast, CD symptoms correlated primarily with gray matter reductions in limbic brain structures. Conclusions: The data suggest that boys with CD and comorbid attention-deficit/hyperactivity disorder show brain abnormalities in frontolimbic areas that resemble structural brain deficits, which are typically observed in adults with antisocial behavior.