Composition of lymph chylomicrons from proximal or distal rat small intestine.
Composition of lymph chylomicrons from proximal or distal rat small intestine.
复制标题
来自近端或远端大鼠小肠的淋巴乳糜微粒的组成。
DOI：
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发表时间：
1980
影响因子：
7.1
通讯作者：
P. Holt
中科院分区：
文献类型：
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作者：
A. L. Wu;S. Clark;P. Holt
在对未麻醉的肠系膜淋巴瘘大鼠进行卵磷脂稳定的三（1- 14 C）油酰甘油乳剂持续灌注期间，比较了大鼠近端和远端小肠分泌的淋巴乳糜微粒的组成。到输注第6小时，当14 C-甘油三酯输出恒定时，远端肠分泌的乳糜微粒磷脂减少33%。远端乳糜微粒较大，甘油三酯：磷脂和载脂蛋白：磷脂比高于近端肠分泌的乳糜微粒。主要的载脂蛋白类-apoB，apoA-I，apoE（=阿普）和C肽-存在于两组乳糜微粒中，但比例不同。与近端乳糜微粒相比，远端乳糜微粒含有较少的apoA-I和较多的C肽，apoC-III 3增加，apoC-III 0减少。本研究表明，远端肠是有缺陷的利用磷脂从肠腔乳糜微粒磷脂合成。远端乳糜微粒的大小和磷脂或载脂蛋白含量的变化是否影响其系统代谢目前尚不清楚。
The composition of lymph chylomicrons secreted by rat proximal and distal small intestine were compared during constant perfusion of a lecithin-stabilized tri (1-14C) oleoyl glycerol emulsion, in pairs of unanesthesized rats with mesenteric lymph fistulas. By the 6th hr of infusion when 14C-triglyceride output was constant, the distal intestine secreted 33% less chylomicron phospholipid. Distal chylomicrons were larger and had higher triglyceride:phospholipid and higher apoprotein:phospholipid ratios than chylomicrons secreted by proximal intestine. The major apoprotein classes--apoB, apoA-I, apoE(= ARP), and C peptides--were present in both groups of chylomicrons, but in different proportions. Distal chylomicrons contained less apoA-I and more C peptides, with an increase in apoC-III3, and a decrease in apoC-III0, compared with proximal chylomicrons. The present study suggests that the distal intestine is defective in the utilization of phospholipid from the intestinal lumen for chylomicron phospholipid synthesis. Whether the observed changes in the size and phospholipid or apoprotein content of distal chylomicrons affect their system metabolism is presently not known.