Controlled patterning of peptide nanotubes and nanospheres using inkjet printing technology
Controlled patterning of peptide nanotubes and nanospheres using inkjet printing technology
复制标题
DOI：
10.1002/psc.963
复制
发表时间：
2008-02-01
影响因子：
2.1
通讯作者：
Gazit, Ehud
中科院分区：
文献类型：
--
作者：
Adler-Abramovich, Lihi;Gazit, Ehud
肽纳米结构由于其优异的自组装特性、生物和化学灵活性以及结构简单性，有望成为未来纳米技术应用的主要工具。然而，将肽组装体整合到功能性电-有机混合装置中的限制因素之一是其组装体的受控图案化。在这里，我们报告使用喷墨技术的应用肽纳米结构的非生物表面。芳香族二肽纳米管（ADNT）在溶液中容易自组装，被用作“墨水”，并使用商业喷墨打印机在透明箔和ITO塑料表面上图案化。虽然喷墨技术在过去用于碳纳米管的图案化，但它不用于生物分子纳米结构的沉积。此外，在应用的开发过程中，我们能够通过相同的芳香族二肽叔丁氧羰基-Phe-Phe-OH（Boc-Phe-Phe-OH）在不同条件下的自组装来产生两种类型的纳米结构，即纳米管和纳米球。球形和管状结构都可以在表面上有效地图案化为预先设计的图案。讨论了这种技术的应用。版权所有（C）2007欧洲肽协会和约翰威利父子有限公司。
Peptide nanostructures are expected to serve as a major tool in future nanotechnological applications owing to their excellent self-assembly properties, biological and chemical flexibility and structural simplicity. Yet one of the limiting factors for the integration of peptide assemblies into functional electro-organic hybrid devices is the controlled patterning of their assemblies. Here we report the use of inkjet technology for the application of peptide nanostructures on nonbiological surfaces. The aromatic dipeptides nanotubes (ADNT) which readily self-assemble in solution were used as an 'ink' and patterned on transparency foil and ITO plastic surfaces using a commercial inkjet printer. While inkjet technology was used in the past for the patterning of carbon nanotubes, it was not used for the deposition of biomolecular nanostructures. Furthermore, during the development of the application we were able to produce two types of nanostructures, i.e. nanotubes and nanospheres by the self-assembly of the same aromatic dipeptide, tertbutoxycarbonyl-Phe-Phe-OH (Boc-Phe-Phe-OH), under different conditions. Both spherical and tubular structures could be efficiently patterned on surfaces into predesigned patterns. The applications of such technology are discussed. Copyright (C) 2007 European Peptide Society and John Wiley & Sons, Ltd.