Blastomycosis‐like pyoderma: Successful treatment with low‐dose acitretin
Blastomycosis‐like pyoderma: Successful treatment with low‐dose acitretin
复制标题
芽生菌病样脓皮病：低剂量阿维A成功治疗
DOI：
10.1111/j.1440-0960.2005.00151.x
复制
发表时间：
2005
影响因子：
2
通讯作者：
G. Beardmore
中科院分区：
文献类型：
--
作者：
R. Nguyen;G. Beardmore
芽生菌病样脓癣通常表现为疣状斑块，脓性分泌物通过多个鼻窦。两例在严重日晒损伤的皮肤上发生芽生菌病样脓癣的患者：一名84岁的男性，有多个疼痛的结节和斑块，一名92岁的女性，左小腿有一个孤立的斑块。组织学显示假上皮瘤样增生伴真皮化脓灶。金黄色葡萄球菌是从第一个病人的活检标本中分离出来的，而后者有普雷沃氏菌和棒状杆菌属。真菌和分枝杆菌检查结果为阴性。这些微生物学结果进一步支持了临床病理诊断。两名患者未能响应口服强力霉素，尽管在体外敏感性的生物体。3-4个月后，两例患者均成功接受了低剂量口服阿维A治疗。
Blastomycosis‐like pyoderma typically presents as verrucous plaque(s) with a purulent discharge through multiple sinuses. Two patients with blastomycosis‐like pyoderma developing on significantly sun‐damaged skin are presented: an 84‐year‐old man with multiple painful nodules and plaques, and a 92‐year‐old woman with a solitary plaque on the left calf. Histopathology showed pseudoepitheliomatous hyperplasia with dermal foci of suppuration. Staphylococcus aureus was isolated from a biopsy specimen in the first patient, whereas the latter patient had Prevotella and Corynebacterium species. Investigations for fungi and mycobacteria yielded negative results. These microbiological findings further supported the clinicopathological diagnosis. Both patients failed to respond to oral doxycycline despite the in vitro susceptibility of the organisms. Treatment with low‐dose oral acitretin was successful in both patients after 3–4 months.