The prognostic significance of HOTAIR for predicting clinical outcome in patients with digestive system tumors
The prognostic significance of HOTAIR for predicting clinical outcome in patients with digestive system tumors
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DOI：
10.1007/s00432-015-1980-8
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发表时间：
2015-12-01
影响因子：
3.6
通讯作者：
Gong, Weida
中科院分区：
文献类型：
--
作者：
Ma, Gaoxiang;Wang, Qiaoyan;Gong, Weida
尽管一些研究评估了 HOTAIR 对消化系统肿瘤患者的预后价值，但 HOTAIR 与消化系统肿瘤预后之间的关系仍不清楚。检索 PubMed 以识别符合条件的研究。在这里，我们对 11 项研究进行了荟萃分析，共 903 例病例。计算了 HOTAIR 对癌症生存的汇总风险比 (HR) 和 95% 置信区间 (CI)。我们发现，与 HOTAIR 低表达患者相比，肿瘤组织中 HOTAIR 表达升高的汇总 HR 为 2.36 (95% CI 1.88-2.97)。此外，亚组分析显示，HOTAIR 过表达还与食管鳞状细胞癌（HR 2.19，95% CI 1.62-2.94）和胃癌（HR 1.66，95% CI 1.02-2.68）的短生存期显着相关。此外，在随访时间较长（随访时间千分之一日元5年）的研究中，上调的HOTAIR与消化系统癌症的生存显着相关（HR 2.51，95 % CI 1.99-3.17）。当按人力资源资源和患者数量进行分层时，结果表明与整体分析结果一致。对种族的亚组分析并没有改变 HOTAIR 表达升高的预后影响。此外，我们还进行了一项独立的验证队列，包括71例胃癌病例，其中HOTAIR表达上调的患者预后不良，HR为2.10（95% CI 1.10-4.03）。结果表明，异常HOTAIR表达可能作为预测消化系统癌患者预后的候选阳性标志物。
Although some studies have assessed the prognostic value of HOTAIR in patients with digestive system tumors, the relationship between the HOTAIR and outcome of digestive system tumors remains unknown.The PubMed was searched to identify the eligible studies. Here, we performed a meta-analysis with 11 studies, including a total of 903 cases. Pooled hazard ratios (HRs) and 95 % confidence interval (CI) of HOTAIR for cancer survival were calculated.We found that the pooled HR elevated HOTAIR expression in tumor tissues was 2.36 (95 % CI 1.88-2.97) compared with patients with low HOTAIR expression. Moreover, subgroup analysis revealed that HOTAIR overexpression was also markedly associated with short survival for esophageal squamous cell carcinoma (HR 2.19, 95 % CI 1.62-2.94) and gastric cancer (HR 1.66, 95 % CI 1.02-2.68). In addition, up-regulated HOTAIR was significantly related to survival of digestive system cancer among the studies with more follow-up time (follow time a parts per thousand yen 5 years) (HR 2.51, 95 % CI 1.99-3.17). When stratified by HR resource and number of patients, the result indicated consistent results with the overall analysis. Subgroup analysis on ethnicities did not change the prognostic influence of elevated HOTAIR expression. Additionally, we conducted an independent validation cohort including 71 gastric cancer cases, in which patients with up-regulated HOTAIR expression had an unfavorable outcome with HR of 2.10 (95 % CI 1.10-4.03).The results suggest that aberrant HOTAIR expression may serve as a candidate positive marker to predict the prognosis of patients with carcinoma of digestive system.