GDF8 inhibits bone formation and promotes bone resorption in mice
GDF8 inhibits bone formation and promotes bone resorption in mice
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GDF8 抑制小鼠骨形成并促进骨吸收。
DOI：
10.1111/1440-1681.12728
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发表时间：
2017-04-01
影响因子：
2.9
通讯作者：
Jiang, Tie-Jian
中科院分区：
文献类型：
--
作者：
Chen, Yu-Si;Guo, Qi;Jiang, Tie-Jian
生长分化因子8 （Growth Differentiation Factor 8, GDF8）又称肌生长抑制素（myostatin），是转化生长因子(TGF)-超级家族的成员。GDF8作为骨骼肌生长的负调节因子，还与骨代谢有关。然而，GDF8在骨代谢中的功能尚不完全清楚。我们的研究旨在探讨GDF8在体外和体内骨代谢中的作用。我们的研究结果表明，GDF8对小鼠原代成骨细胞具有负调控作用，并促进核因子B配体受体激活因子（RANKL）诱导的体外破骨细胞生成。腹腔注射重组GDF8抑制小鼠骨形成，加速骨吸收。此外，用GDF8中和抗体治疗老年小鼠可刺激新骨形成并阻止骨吸收。因此，我们的研究表明GDF8在骨形成和骨吸收中起着重要的调节作用，从而为骨质疏松症提供了潜在的治疗途径。
Growth Differentiation Factor 8 (GDF8), also called myostatin, is a member of the transforming growth factor (TGF)- super-family. As a negative regulator of skeletal muscle growth, GDF8 is also associated with bone metabolism. However, the function of GDF8 in bone metabolism is not fully understood. Our study aimed to investigate the role of GDF8 in bone metabolism, both in vitro and in vivo. Our results showed that GDF8 had a negative regulatory effect on primary mouse osteoblasts, and promoted receptor activator of nuclear factor B ligand (RANKL)-induced osteoclastogenesis in vitro. Intraperitoneal injection of recombinant GDF8 repressed bone formation and accelerated bone resorption in mice. Furthermore, treatment of aged mice with a GDF8 neutralizing antibody stimulated new bone formation and prevented bone resorption. Thus, our study showed that GDF8 plays a significant regulatory role in bone formation and bone resorption, thus providing a potential therapeutic pathway for osteoporosis.