Excitotoxic insult due to ibogaine leads to delayed induction of neuronal NOS in Purkinje cells.
Excitotoxic insult due to ibogaine leads to delayed induction of neuronal NOS in Purkinje cells.
复制标题
伊博加因引起的兴奋性毒性损伤导致浦肯野细胞中神经元 NOS 的诱导延迟。
DOI：
10.1097/00001756-199508000-00006
复制
发表时间：
1995
期刊：
影响因子：
1.7
通讯作者：
Molliver,ME
中科院分区：
文献类型：
--
作者：
O'Hearn,E;Zhang,P;Molliver,ME
Ibogaine causes degeneration of Purkinje cells (PKCs), presumably via activation of neurons in the inferior olive leading to release of glutamate at climbing fiber terminals. Following ibogaine administration, some Purkinje cells express NADPH-diaphorase and neuronal NOS (nNOS), neither of which is present normally in these cells. The induction of NOS is delayed in onset, dose-related, and detected in neurons adjacent to degenerated PKCs. The results demonstrate that nNOS induction can follow excitotoxic neuronal injury or perturbation. However, NO is unlikely to participate in the initial phase of PKC damage. Both the late induction of nNOS and the spatial relationship between damaged and nNOS-expressing PKCs are consistent with a role for NO in either neuronal recovery or delayed cell death following excitotoxic injury.
