Role of sigmoidoscopy in screening for colorectal cancer: a critical review.
Role of sigmoidoscopy in screening for colorectal cancer: a critical review.
复制标题
乙状结肠镜检查在结直肠癌筛查中的作用：批判性评论。
DOI：
10.1016/0016-5085(88)90511-2
复制
发表时间：
1988
期刊：
影响因子：
29.4
通讯作者：
Pita,S
中科院分区：
文献类型：
--
作者：
Neugut,AI;Pita,S
乙状结肠镜作为结直肠癌的筛查方法存在争议。对有关其疗效的证据进行严格审查，特别注意筛查研究中的潜在偏差。绝大多数研究是不受控制的，没有后续信息，因此对乙状结肠镜的实际益处知之甚少。两项随访的非对照研究和一项随机试验表明，乙状结肠镜检查的使用降低了结直肠癌的死亡率，但这三项研究都有主要缺点。作者得出结论，目前可用的数据不足以建立乙状结肠镜筛查的国家推荐。为了建立这样的建议，需要进行一项以结直肠癌死亡率为结果的适当的随机试验。
The use of sigmoidoscopy as a screening method for colorectal cancer is controversial. Evidence regarding its efficacy is reviewed critically, with special attention given to potential biases in screening studies. The vast majority of studies are uncontrolled and without follow-up information and thus shed little light on the actual benefits of sigmoidoscopy. Two uncontrolled studies with follow-up and one randomized trial suggest a colorectal cancer mortality reduction because of the use of sigmoidoscopy, but all three studies have major shortcomings. The authors conclude that the currently available data are insufficient to establish a national recommendation for screening with sigmoidoscopy. To establish such a recommendation, a properly conducted randomized trial with colorectal cancer mortality as an outcome is needed.