A Class of Cationic Triblock Amphiphilic Oligopeptides as Efficient Gene-Delivery Vectors
A Class of Cationic Triblock Amphiphilic Oligopeptides as Efficient Gene-Delivery Vectors
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DOI：
10.1002/adma.200800928
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发表时间：
2009-01-05
影响因子：
29.4
通讯作者：
Yang, Yi-Yan
中科院分区：
文献类型：
--
作者：
Seow, Wei Yang;Yang, Yi-Yan
设计了一类新型三嵌段寡肽，包含用于 DNA 结合的精氨酸、用于细胞内缓冲的组氨酸和用于增强细胞摄取的疏水残基，每个嵌段都提供有效基因递送所必需的独特功能。与 PEI 标准相比，这些材料共同表现出强大的 DNA 结合能力、低细胞毒性和显着更高的体内基因转染效率。
A new class of triblock oligopeptides, containing arginine for DNA binding, histidine for intracellular buffering, and hydrophobic residues for enhanced cellu lar uptake has been designed, with each block offering unique functionalities essential for efficient gene delivery. Together, these materials demonstrate strong DNA binding ability, low cytotoxicity, and significantly higher in vivo gene-transfection efficiency compared to the PEI standard.