Collagenases (first of three parts).
Collagenases (first of three parts).
复制标题
胶原酶（三部分中的第一部分）。
DOI：
10.1056/nejm197409122911105
复制
发表时间：
1974
期刊：
影响因子：
--
通讯作者：
S. Krane
中科院分区：
文献类型：
--
作者：
E. D. Harris;S. Krane
胶原酶在正常生理和病理中的特殊作用风湿性关节炎-滑膜胶原酶在慢性活动性风湿性关节炎中，关节破坏的两种主要机制已经被假定：一种是机械的，另一种是酶的。在前者中，有人提出，没有直接的证据，破碎和机械故障后，可以发生蛋白聚糖从软骨基质和其他结缔组织成分耗尽。远离肉芽组织的关节炎关节软骨中的蛋白多糖经常被耗尽。137这种状态下的软骨抵抗变形的能力减弱156，并且更容易因压力（如负重）而碎裂。然而，它是. ... . .
Specific Involvement of Collagenase in Normal Physiology and PathologyRheumatoid Arthritis — Synovial CollagenaseIn chronic active rheumatoid arthritis two principal mechanisms for joint destruction have been postulated: one is mechanical, and the other enzymatic. In the former, it has been proposed, without direct demonstration, that fragmentation and mechanical breakdown can occur after depletion of proteoglycans from cartilage matrix and other connective-tissue components. Articular cartilage in arthritis remote from granulations is frequently depleted of proteoglycans.137Cartilage in this state has a diminished capacity to resist deformation156and could be more easily fragmented by stress such as weight-bearing. However, it is . . .