Inadequate sleep as a risk factor for obesity: Analyses of the NHANES I
Inadequate sleep as a risk factor for obesity: Analyses of the NHANES I
复制标题
DOI：
10.1093/sleep/28.10.1289
复制
发表时间：
2005-10-01
期刊：
影响因子：
5.6
通讯作者：
Heymsfield, SB
中科院分区：
文献类型：
--
作者：
Gangwisch, JE;Malaspina, D;Heymsfield, SB
研究目的：睡眠剥夺被认为是通过降低瘦素、增加饥饿素和损害胰岛素敏感性而导致肥胖的原因。本研究调查了美国大样本的横截面和纵向数据，以确定睡眠时间是否与肥胖和体重增加有关。设计：1982- 1984、1987和1992年NHANES I随访研究的纵向分析和1982-1984年研究的横截面分析。美国平民非机构化人口的概率样本。参与者：横向分析的样本量为9，588，1987年为8，073，1992年为6，981。1982-1984年测量体重，1987年和1992年自我报告体重。年龄在32岁至49岁之间，自报基线睡眠时间少于7小时的受试者的平均体重指数高于睡眠时间为7小时的受试者，更有可能肥胖。在横截面和纵向结果中，睡眠时间超过7小时与肥胖可能性的增加或减少并不一致。基线时每增加一小时的睡眠与随访期间体重指数的变化呈负相关，但这种关联很小，统计学意义不显著。结论：这些研究结果支持这一假设，即睡眠时间与肥胖在一个大的纵向监测美国样本。这些观察结果支持了早期的实验性睡眠研究，并为未来关于增加睡眠数量和质量的体重控制干预措施的研究提供了基础。
Study Objectives: Sleep deprivation has been hypothesized to contribute toward obesity by decreasing leptin, increasing ghrelin, and compromising insulin sensitivity. This study examines cross-sectional and longitudinal data from a large United States sample to determine whether sleep duration is associated with obesity and weight gain.Design: Longitudinal analyses of the 1982-1984,1987, and 1992 NHANES I Followup Studies and cross-sectional analysis of the 1982-1984 study.Setting: Probability sample of the civilian noninstitutionalized population of the United States.Participants: Sample sizes of 9,588 for the cross-sectional analyses, 8,073 for the 1987, and 6,981 for the 1992 longitudinal analyses.Measurements and Results: Measured weight in 1982-1984 and self-reported weights in 1987 and 1992. Subjects between the ages of 32 and 49 years with self-reported sleep durations at baseline less than 7 hours had higher average body mass indexes and were more likely to be obese than subjects with sleep durations of 7 hours. Sleep durations over 7 hours were not consistently associated with either an increased or decreased likelihood of obesity in the cross-sectional and longitudinal results. Each additional hour of sleep at baseline was negatively associated with change in body mass index over the follow-up period, but this association was small and statistically insignificant.Conclusions: These findings support the hypothesis that sleep duration is associated with obesity in a large longitudinally monitored United States sample. These observations support earlier experimental sleep studies and provide a basis for future studies on weight control interventions that increase the quantity and quality of sleep.