ASSOCIATION OF HLA ANTIGENS AND TOTAL SERUM IMMUNOGLOBULIN-E LEVEL WITH ALLERGIC RESPONSE AND FAILURE TO RESPOND TO RAGWEED ALLERGEN RA3
ASSOCIATION OF HLA ANTIGENS AND TOTAL SERUM IMMUNOGLOBULIN-E LEVEL WITH ALLERGIC RESPONSE AND FAILURE TO RESPOND TO RAGWEED ALLERGEN RA3
复制标题
DOI：
10.1073/pnas.76.6.2903
复制
发表时间：
1979-01-01
影响因子：
11.1
通讯作者：
BIAS, WB
中科院分区：
文献类型：
--
作者：
MARSH, DG;CHASE, GA;BIAS, WB
对豚草次要过敏原Ra3具有不同敏感性的过敏个体的人类免疫应答和人类白细胞抗原（HLA）数据进行了严格的统计分析。通过对一系列Ra3应答者和无应答者亚组进行回归分析，获得了支持离散应答者和无应答者表型概念的数据。发现Ra3应答与血清总IgE（免疫球蛋白E）以及A2交叉反应组（A2和A28）的HLA抗原存在显著正相关，与A3交叉反应组（A3和A11）的抗原存在显著负相关。HLA - A位点的等位基因显然可能作为免疫应答或免疫抑制基因发挥作用，或者此类等位基因对于应答或抑制基因是上位性的。与HLA相关的特异性IgE应答显然受到基础IgE水平的遗传调控的强烈影响。
Rigorous statistical analysis was applied to human immune response and HLA data in allergic subjects having varying sensitivity to the minor ragweed allergen, Ra3. By using regression analysis on a series of subsets of Ra3 responders and nonresponders, data supporting the concept of discrete responder and nonresponder phenotypes was obtained. Significant positive associations between Ra3 response and total serum Ig[immunoglobulin]E and the presence of HLA antigens of the A2 crossreacting group (A2 and A28), and significant negative associations with antigens of the A3 crossreacting group (A3 and A11) were found. Alleles of the HLA-A locus apparently may function as immune response or immune suppressor genes or such alleles are epistatic to the response or suppressor genes. HLA-associated specific IgE response is apparently strongly influenced by genetic regulation of basal IgE level.