Modelling biopharmaceutical manufacture: Design and implementation of SimBiopharma
Modelling biopharmaceutical manufacture: Design and implementation of SimBiopharma
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DOI：
10.1016/j.compchemeng.2006.10.020
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发表时间：
2007-09-01
影响因子：
4.3
通讯作者：
Titchener-Hooker, Nigel J.
中科院分区：
文献类型：
--
作者：
Farid, Suzanne S.;Washbrook, John;Titchener-Hooker, Nigel J.
本文介绍了一个概念框架的实现，用于将生物制药制造工厂建模为原型决策支持工具SimBiopharma。该工具的范围涵盖了在成本、时间、产量、资源利用和风险方面评估制造替代方案的能力。考虑不确定性意味着投资评估可以根据预期产出和实现这些产出的可能性。介绍了一种表示制造过程中关键活动的分层方法。重点放在如何通过在面向对象的环境G2 （Gensym Corporation, Cambridge， MA）中捕获公共信息来实现生物过程和业务过程建模的更紧密集成。重点介绍了SimBIOPHARMA的主要特点；其中包括交互式图形、面向任务的表示和动态仿真，它们为建模过程创造了更加灵活的环境。给出了SimBIOPHARMA在处理生产选择对战略业务和财务指标的影响时产生的典型产出的例子。(c) 2006 Elsevier Ltd.版权所有。
This paper presents the implementation of a conceptual framework, for modelling a biopharmaceutical manufacturing plant, into a prototype decision-support tool, SimBiopharma. The tool's scope covers the ability to evaluate manufacturing alternatives in terms of cost, time, yield, resource utilisation and risk. Incorporating uncertainty means that investment appraisal can be based on both the expected outputs and the likelihood of achieving them. A hierarchical approach to represent the key activities in a manufacturing process is introduced. Emphasis is placed on how a closer integration of bioprocess and business process modelling can be achieved by capturing common information in an object-oriented environment, G2 (Gensym Corporation, Cambridge, MA). The key features of SimBIOPHARMA are highlighted; these include interactive graphics, task-oriented representation and dynamic simulation which create a much more flexible environment for modelling processes. Examples of typical outputs generated by SimBIOPHARMA, when addressing the impact of manufacturing options on strategic operational and financial indicators, are given. (c) 2006 Elsevier Ltd. All rights reserved.